Squair Jordan W, Berney Maxime, Castro Jimenez Mayte, Hankov Nicolas, Demesmaeker Robin, Amir Suje, Paley Aurelie, Hernandez-Charpak Sergio, Dumont Gregory, Asboth Leonie, Allenbach Gilles, Becce Fabio, Schoettker Patrick, Wuerzner Gregoire, Bally Julien F, Courtine Grégoire, Bloch Jocelyne
From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
N Engl J Med. 2022 Apr 7;386(14):1339-1344. doi: 10.1056/NEJMoa2112809.
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood pressure and enable a patient with multiple-system atrophy to stand and walk after having lost these abilities because of orthostatic hypotension. This system involved epidural electrical stimulation delivered over the thoracic spinal cord with accelerometers that detected changes in body position. (Funded by the Defitech Foundation.).
直立性低血压是多系统萎缩的主要特征。直立姿势会引发晕厥发作，使患者无法站立和行走超过短暂时间。我们植入了一个系统来恢复血压调节功能，使一名因直立性低血压而丧失这些能力的多系统萎缩患者能够站立和行走。该系统包括通过置于胸段脊髓上的加速度计检测身体位置变化，进行硬膜外电刺激。（由德菲泰克基金会资助。）
