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两例严重、有症状的克氏锥虫心肌病犬用伊曲康唑和胺碘酮进行抗寄生虫治疗。

Antiparasitic treatment with itraconazole and amiodarone in 2 dogs with severe, symptomatic Chagas cardiomyopathy.

机构信息

Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

Heart of Veterinary Cardiology PLLC, Seattle, Washington, USA.

出版信息

J Vet Intern Med. 2022 May;36(3):1100-1105. doi: 10.1111/jvim.16422. Epub 2022 Apr 7.

DOI:10.1111/jvim.16422
PMID:35388923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9151465/
Abstract

Chagas cardiomyopathy, caused by the protozoal parasite Trypanosoma cruzi, is characterized by arrhythmias, myocardial damage, heart failure, and sudden death. We describe 2 dogs with severe, symptomatic Chagas cardiomyopathy characterized by myocardial dysfunction and electrocardiographic abnormalities that were managed with a combination of cardiac medications and antiparasitic treatment with itraconazole and amiodarone. Both dogs died suddenly within 6 months of diagnosis. These cases highlight the need for early detection of Chagas disease in dogs and continued research to develop effective antiparasitic treatment protocols.

摘要

克氏锥虫引起的恰加斯心肌病的特征是心律失常、心肌损伤、心力衰竭和猝死。我们描述了 2 只患有严重、有症状的恰加斯心肌病的狗,其特征是心肌功能障碍和心电图异常,通过联合使用心脏药物以及伊曲康唑和胺碘酮进行抗寄生虫治疗来进行管理。这两只狗在诊断后 6 个月内均突然死亡。这些病例强调了早期发现犬类恰加斯病的必要性,以及需要继续研究开发有效的抗寄生虫治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f5/9151465/d6e37611edcd/JVIM-36-1100-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f5/9151465/70f6cdde2278/JVIM-36-1100-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f5/9151465/d6e37611edcd/JVIM-36-1100-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f5/9151465/70f6cdde2278/JVIM-36-1100-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9f5/9151465/d6e37611edcd/JVIM-36-1100-g002.jpg

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