Matthews Derek J, Fries Ryan C, Jeffery Nicholas D, Hamer Sarah A, Saunders Ashley B
Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA.
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA.
Animals (Basel). 2023 Apr 18;13(8):1393. doi: 10.3390/ani13081393.
infection causes inflammation and fibrosis, resulting in cardiac damage in dogs. The objectives of this study were to describe cardiac magnetic resonance imaging (CMR) in naturally infected dogs with chronic Chagas disease and the frequency of abnormalities for CMR and cardiac diagnostic tests. Ten asymptomatic, client-owned dogs seropositive for were prospectively enrolled in an observational study evaluating echocardiography, ECG (standard and ambulatory), cardiac troponin I (cTnI), and CMR. Standard ECG measurements (3/10) and cTnI concentration (1/10) outside the reference range were uncommon. Ambulatory ECG abnormalities were documented more frequently (6/10 dogs) than with standard ECG and included ventricular arrhythmias (4), supraventricular premature beats (3), second-degree atrioventricular block (2), and sinus arrest (1). Echocardiographic abnormalities were documented in 6/10 dogs including mildly increased left ventricular internal dimension in diastole (1) and decreased right ventricular (RV) systolic function based on reductions in tricuspid annular plane systolic excursion (3) and RV S' (4). Abnormalities were detected with CMR in 7/10 dogs including delayed myocardial enhancement in 5 of which 2 also had increased extracellular volume, abnormal wall motion in 5, and loss of apical compact myocardium in 1. In conclusion, CMR abnormalities were common, and the results of this study suggest CMR can provide useful information in dogs with infection and may support naturally infected dogs for future clinical investigation as an animal model for Chagas disease.
感染会引发炎症和纤维化，导致犬类心脏损伤。本研究的目的是描述慢性恰加斯病自然感染犬的心脏磁共振成像（CMR）情况，以及CMR和心脏诊断测试异常的频率。十只无症状的、客户拥有的犬只因[此处原文缺失具体血清学检测项目]血清学呈阳性，被前瞻性纳入一项观察性研究，评估超声心动图、心电图（标准和动态）、心肌肌钙蛋白I（cTnI）和CMR。标准心电图测量值（3/10）和cTnI浓度（1/10）超出参考范围的情况并不常见。动态心电图异常的记录比标准心电图更频繁（6/10只犬），包括室性心律失常（4例）、室上性早搏（3例）、二度房室传导阻滞（2例）和窦性停搏（1例）。10只犬中有6只记录到超声心动图异常，包括舒张期左心室内径轻度增加（1例），以及基于三尖瓣环平面收缩期位移降低（3例）和右心室S'降低（4例）导致的右心室（RV）收缩功能下降。10只犬中有7只通过CMR检测到异常，包括5只延迟心肌强化，其中2只还伴有细胞外容积增加，5只壁运动异常，1只心尖致密心肌丧失。总之，CMR异常很常见，本研究结果表明CMR可为感染[此处原文缺失具体感染源]的犬提供有用信息，并可能支持将自然感染犬作为恰加斯病的动物模型用于未来的临床研究。
