Department of General Surgery, Jinshan Hospital, Fudan University, Shanghai, P. R. China.
Department of Surgery, Shanghai Medical College, Fudan University, Shanghai, P. R. China.
Bioengineered. 2022 Apr;13(4):9467-9481. doi: 10.1080/21655979.2022.2060778.
Hepatocellular carcinoma (HCC) has a high recurrence rate and mortality rate even after surgery. Low-density lipoprotein receptor-related protein 1B (LRP1B) has proven to be involved in tumor development and progression of multiple malignancies. However, the function of in HCC progression has not been fully elucidated. Thus, we conducted this study to explore the relationship between and HCC. Bioinformatic analyses implied that was highly expressed in HCC tissues. High expression was shown to be related to poor outcomes and the determination of HCC patients' tumor stage. deletion impeded the proliferation, migration, and invasion of HCC cells. Further investigation demonstrated that silencing expression enhanced the sensitivity of HCC cells to doxorubicin. deletion inhibited HCC progression by regulating the PERK-ATF4-CHOP signaling pathway. Additionally, we probed the genomic alterations of in HCC and the impact on the prognosis of patients. Collectively, our results suggest that plays an essential role in the promotion of HCC progression by regulating the PERK-ATF4-CHOP signaling pathway, which is a potential prognostic biomarker and a promising therapeutic target of HCC.
肝细胞癌 (HCC) 即使在手术后也有很高的复发率和死亡率。载脂蛋白 B 受体相关蛋白 1B（LRP1B）已被证明参与多种恶性肿瘤的肿瘤发生和进展。然而，在 HCC 进展中的功能尚未完全阐明。因此，我们进行了这项研究，以探讨 与 HCC 之间的关系。生物信息学分析表明， 在 HCC 组织中高表达。高 表达与不良预后和 HCC 患者肿瘤分期的确定有关。 的缺失阻碍了 HCC 细胞的增殖、迁移和侵袭。进一步的研究表明，沉默 表达可增强 HCC 细胞对阿霉素的敏感性。 通过调节 PERK-ATF4-CHOP 信号通路抑制 HCC 进展。此外，我们还研究了 HCC 中 的基因组改变及其对患者预后的影响。综上所述，我们的研究结果表明， 通过调节 PERK-ATF4-CHOP 信号通路在促进 HCC 进展中发挥重要作用，是 HCC 的一个有前途的预后生物标志物和治疗靶点。
