多胺氧化产生的纯化氨基醛对恶性疟原虫在正常及葡萄糖-6-磷酸脱氢酶缺乏的红细胞中体外发育的影响。
The effect of purified aminoaldehydes produced by polyamine oxidation on the development in vitro of Plasmodium falciparum in normal and glucose-6-phosphate-dehydrogenase-deficient erythrocytes.
作者信息
Morgan D M, Bachrach U, Assaraf Y G, Harari E, Golenser J
出版信息
Biochem J. 1986 May 15;236(1):97-101. doi: 10.1042/bj2360097.
Abstract
Purified aminoaldehydes produced by polyamine oxidation were toxic to the malarial parasite, Plasmodium falciparum, cultured in human erythrocytes. There was a profound effect on young ring forms, and, during maturation, parasites became more sensitive to the aldehydes. Oxidation of the aldehydes abolished the lethal effect. The plasmodia within glucose-6-phosphate-dehydrogenase (G6PD)-deficient erythrocytes were more sensitive to mono- and di-aldehydes than were parasites in normal erythrocytes. G6PD-deficient erythrocytes were also more sensitive to pretreatment with the dialdehyde produced by the oxidation of spermine. Pretreatment prevented further invasion by the parasites.
摘要
多胺氧化产生的纯化氨基醛对在人红细胞中培养的疟原虫恶性疟原虫有毒性。对年轻环状体有深远影响，并且在成熟过程中，寄生虫对醛类变得更敏感。醛的氧化消除了致死作用。葡萄糖-6-磷酸脱氢酶（G6PD）缺乏的红细胞内的疟原虫比正常红细胞中的寄生虫对单醛和二醛更敏感。G6PD缺乏的红细胞对用精胺氧化产生的二醛预处理也更敏感。预处理可防止寄生虫进一步入侵。
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