类风湿性关节炎滑液中的多胺氧化酶活性
Polyamine oxidase activity in rheumatoid arthritis synovial fluid.
作者信息
Ferrante A, Storer R J, Cleland L J
机构信息
Department of Immunology, Adelaide Children's Hospital, South Australia.
出版信息
Clin Exp Immunol. 1990 Jun;80(3):373-5. doi: 10.1111/j.1365-2249.1990.tb03295.x.
Abstract
Oxidation of polyamides by polyamine oxidases (PAO) leads to the generation of highly reactive aminoaldehydes which have been shown to have a variety of effects, including killing of pathogenic microorganisms and regulation of leucocyte functions. Data presented here show that PAO are present in synovial fluid from patients with rheumatoid arthritis. This finding may have important implications in the various properties attributed to synovial fluid which includes anti-inflammatory activity.
摘要
多胺氧化酶（PAO）对聚酰胺的氧化作用会导致产生高反应性氨基醛，这些氨基醛已被证明具有多种作用，包括杀死病原微生物和调节白细胞功能。此处呈现的数据表明，类风湿性关节炎患者的滑液中存在PAO。这一发现可能对滑液所具有的包括抗炎活性在内的各种特性具有重要意义。
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