一名石棉沉着病患者的病理分级与肺纤维浓度之间的关系。
Relation between pathological grading and lung fibre concentration in a patient with asbestosis.
作者信息
Gylseth B, Skaug V
出版信息
Br J Ind Med. 1986 Nov;43(11):754-9. doi: 10.1136/oem.43.11.754.
The fibre concentration and extent and severity of fibrosis have been analysed in 48 specimens from the left lung of a patient with asbestosis. Two different methods of fibre analysis were used. The results obtained by transmission electron microscopy were 2-2.5 times higher than those obtained by scanning electron microscopy. Low temperature ashed samples showed on average twice the number of fibres obtained after wet digestion of the samples. The transmission electron microscope detected considerably shorter fibres than the scanning electron microscope. Low temperature ashing produced also shorter fibres compared with the wet digestion procedure. A statistically significant correlation between fibre concentration and the grade of fibrosis was found only for low temperature ashed samples analysed in the transmission electron microscope. When dividing the lung into nine anatomical compartments and pooling the grade of fibrosis and the fibre concentration data within each compartment, an even better correlation was obtained.
对一名石棉沉着病患者左肺的48个标本进行了纤维浓度、纤维化程度和严重程度分析。使用了两种不同的纤维分析方法。透射电子显微镜获得的结果比扫描电子显微镜获得的结果高2至2.5倍。低温灰化样品显示的纤维数量平均是样品湿消化后获得的纤维数量的两倍。透射电子显微镜检测到的纤维比扫描电子显微镜检测到的纤维短得多。与湿消化程序相比，低温灰化产生的纤维也更短。仅在透射电子显微镜分析的低温灰化样品中，发现纤维浓度与纤维化分级之间存在统计学上的显著相关性。将肺分为九个解剖区域，并汇总每个区域内的纤维化分级和纤维浓度数据时，获得了更好的相关性。
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