近期咪唑并[1,5-a]吡啶及相关杂环的合成方法学。
Recent synthetic methodologies for imidazo[1,5-]pyridines and related heterocycles.
机构信息
James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA, 45267-0514.
Paraza Pharma Inc., Montreal, Canada, H4S 2E1.
出版信息
Org Biomol Chem. 2022 May 4;20(17):3440-3468. doi: 10.1039/d2ob00386d.
Imidazo[1,5-]pyridine is a significant structural component of a large number of agrochemicals and pharmaceuticals. The synthesis of imidazo[1,5-]pyridine has been a subject of intense research for numerous decades. A large number of transformations are now available to conveniently access imidazo[1,5-]pyridine from readily available starting materials. This review details the recent development in imidazo[1,5-]pyridine construction involving cyclocondensation, cycloaddition, oxidative cyclization, and transannulation reactions.
咪唑并[1,5-a]吡啶是大量农药和药物的重要结构组成部分。咪唑并[1,5-a]吡啶的合成是数十年来研究的热点。现在有大量的转化方法可以从易得的起始原料方便地得到咪唑并[1,5-a]吡啶。本综述详细介绍了涉及环缩合、环加成、氧化环化和transannulation 反应的咪唑并[1,5-a]吡啶构建的最新发展。
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