一锅法酸催化合成双(1-咪唑并[1,5 -]吡啶基)芳基甲烷及其细胞毒性活性评价
One-pot acid-catalysed synthesis of bis(1-imidazo[1,5-]pyridyl)arylmethanes and evaluation of cytotoxic activities.
作者信息
Hung Tran Quang, Phuc Ban Van, Do Ha Nam, Tran Thu Hue, Nguyen Hai Yen, Truong Phuoc Nguyen, Chi Truong Mai, Do Dang Van, Nga Truong T T, Nguyen Hien, Nguyen Van Tuyen, Dang Tuan Thanh
机构信息
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet Hanoi Vietnam
Faculty of Chemistry, VNU-Hanoi University of Science 19 Le Thanh Tong Hanoi Vietnam
出版信息
RSC Adv. 2025 Feb 10;15(6):4274-4280. doi: 10.1039/d4ra08868a. eCollection 2025 Feb 6.
A practical and efficient approach for the acid-catalysed synthesis of bis(1-imidazo[1,5-]pyridyl)arylmethane (BimPy) derivatives has been described. Interestingly, these BimPys showed potential cytotoxicity against various cancer cell lines (SK-LU-1, MCF-7, HepG2).
已描述了一种实用且高效的酸催化合成双(1-咪唑并[1,5 -]吡啶基)芳基甲烷(BimPy)衍生物的方法。有趣的是，这些BimPy对多种癌细胞系(SK-LU-1、MCF-7、HepG2)显示出潜在的细胞毒性。
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