Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Org Lett. 2022 Apr 22;24(15):2910-2914. doi: 10.1021/acs.orglett.2c00882. Epub 2022 Apr 8.
A convenient and straightforward approach for the construction of indole alkaloid scaffolds from indole-containing alkene-tethered aryl halides and alkynes through a sequential C-H activation, five-membered palladacycle formation, and alkyne insertion process has been described. The approach provides a series of indole alkaloid compounds in moderate to excellent yields with good functional tolerance.
一种方便直接的方法，可通过顺序 C-H 活化、五元钯环形成和炔烃插入过程，从含吲哚的烯丙基芳基卤化物和炔烃构建吲哚生物碱支架。该方法以中等到优异的产率提供了一系列吲哚生物碱化合物，具有良好的功能耐受性。
