Sørensen Mette, Andersen-Ranberg Johan, Hankamer Ben, Møller Birger Lindberg
Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark.
Institute of Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Trends Plant Sci. 2022 Jul;27(7):655-673. doi: 10.1016/j.tplants.2022.03.001. Epub 2022 Apr 5.
Using synthetic biology, it is now time to expand the biosynthetic repertoire of plants and microalgae by utilizing the chloroplast to augment the production of desired high-value compounds and of oil-, carbohydrate-, or protein-enriched biomass based on direct harvesting of solar energy and the consumption of CO. Multistream product lines based on separate commercialization of the isolated high-value compounds and of the improved bulk products increase the economic potential of the light-driven production system and accelerate commercial scale up. Here we outline the scientific basis for the establishment of such green circular biomanufacturing systems and highlight recent results that make this a realistic option based on cross-disciplinary basic and applied research to advance long-term solutions.
利用合成生物学，现在是时候通过利用叶绿体来扩大植物和微藻的生物合成能力了，以便基于直接收集太阳能和消耗二氧化碳来增加所需高价值化合物以及富含油、碳水化合物或蛋白质的生物质的产量。基于分离出的高价值化合物和改良大宗产品的单独商业化的多流产品线，提高了光驱动生产系统的经济潜力，并加速了商业规模扩大。在此，我们概述了建立此类绿色循环生物制造系统的科学依据，并强调了近期的研究成果，这些成果基于跨学科的基础研究和应用研究，使这成为推进长期解决方案的现实选择。
