Yeh Mei-Yu, Chen Henry S, Hou Ping, Kumar Vinodh A, Johnson Jason M, Noll Kyle R, Prabhu Sujit S, Ferguson Sherise D, Schomer Donald F, Peng Hsu-Hsia, Liu Ho-Ling
Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
J Magn Reson Imaging. 2022 Dec;56(6):1863-1871. doi: 10.1002/jmri.28194. Epub 2022 Apr 9.
Recently, a data-driven regression analysis method was developed to utilize the resting-state (rs) blood oxygenation level-dependent signal for cerebrovascular reactivity (CVR) mapping (rs-CVR), which was previously optimized by comparing with the CO inhalation-based method in health subjects and patients with neurovascular diseases.
To investigate the agreement of rs-CVR and the CVR mapping with breath-hold MRI (bh-CVR) in patients with gliomas.
Retrospective.
Twenty-five patients (12 males, 13 females; mean age ± SD, 48 ± 13 years) with gliomas.
FIELD STRENGTH/SEQUENCE: Dynamic T2*-weighted gradient-echo echo-planar imaging during a breath-hold paradigm and during the rs on a 3-T scanner.
rs-CVR with various frequency ranges and resting-state fluctuation amplitude (RSFA) were assessed. The agreement between each rs-based CVR measurement and bh-CVR was determined by voxel-wise correlation and Dice coefficient in the whole brain, gray matter, and the lesion region of interest (ROI).
Voxel-wise Pearson correlation, Dice coefficient, Fisher Z-transformation, repeated-measure analysis of variance and post hoc test with Bonferroni correction, and nonparametric repeated-measure Friedman test and post hoc test with Bonferroni correction were used. Significance was set at P < 0.05.
Compared with bh-CVR, the highest correlations were found at the frequency bands of 0.04-0.08 Hz and 0.02-0.04 Hz for rs-CVR in both whole brain and the lesion ROI. RSFA had significantly lower correlations than did rs-CVR of 0.02-0.04 Hz and a wider frequency range (0-0.1164 Hz). Significantly higher correlations and Dice coefficient were found in normal tissues than in the lesion ROI for all three methods.
The optimal frequency ranges for rs-CVR are determined by comparing with bh-CVR in patients with gliomas. The rs-CVR method outperformed the RSFA. Significantly higher correlation and Dice coefficient between rs- and bh-CVR were found in normal tissue than in the lesion.
3 TECHNICAL EFFICACY STAGE: 2.
最近，一种数据驱动的回归分析方法被开发出来，用于利用静息态（rs）血氧水平依赖信号进行脑血管反应性（CVR）映射（rs-CVR），该方法先前已通过在健康受试者和神经血管疾病患者中与基于吸入一氧化碳的方法进行比较而得到优化。
研究rs-CVR与呼吸屏气磁共振成像（bh-CVR）在胶质瘤患者中的一致性。
回顾性研究。
25例胶质瘤患者（12例男性，13例女性；平均年龄±标准差，48±13岁）。
场强/序列：在3-T扫描仪上，于呼吸屏气模式和静息态期间进行动态T2*加权梯度回波平面回波成像。
评估不同频率范围的rs-CVR和静息态波动幅度（RSFA）。通过全脑、灰质和感兴趣病变区域（ROI）的体素相关性和Dice系数来确定基于rs的每种CVR测量值与bh-CVR之间的一致性。
使用体素-wise Pearson相关性、Dice系数、Fisher Z变换、重复测量方差分析和Bonferroni校正的事后检验，以及非参数重复测量Friedman检验和Bonferroni校正的事后检验。显著性设定为P < 0.05。
与bh-CVR相比，在全脑和病变ROI中，rs-CVR在0.04 - 0.08Hz和0.02 - 0.04Hz频段发现最高相关性。RSFA的相关性显著低于0.02 - 0.04Hz的rs-CVR，且频率范围更宽（0 - 0.1164Hz）。对于所有三种方法，在正常组织中发现的相关性和Dice系数显著高于病变ROI。
通过与胶质瘤患者的bh-CVR比较确定了rs-CVR的最佳频率范围。rs-CVR方法优于RSFA。在正常组织中，rs-CVR与bh-CVR之间的相关性和Dice系数显著高于病变组织。
3级 技术效能阶段：2级
