Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Jul;14(4):e1793. doi: 10.1002/wnan.1793. Epub 2022 Apr 9.
Despite current advances in new approaches for cancer detection and treatment, pancreatic cancer remains one of the most lethal cancer types. Difficult to detect early, aggressive tumor biology, and resistance to chemotherapy, radiotherapy, and immunotherapy result in a poor prognosis of pancreatic cancer patients with a 5-year survival of 10%. With advances in cancer nanotechnology, new imaging and drug delivery approaches that allow the development of multifunctional nanotheranostic agents offer opportunities for improving pancreatic cancer treatment using precision oncology. In this review, we will introduce potential applications of innovative theranostic strategies to address major challenges in the treatment of pancreatic cancer at different disease stages. Several important issues concerning targeted delivery of theranostic nanoparticles and tumor stromal barriers are discussed. We then focus on the development of a magnetic iron oxide nanoparticle platform for multimodal therapy of pancreatic cancer, including MRI monitoring targeted nanoparticle/drug delivery, therapeutic response, and tumor re-staging, activation of tumor immune response by immunoactivating nanoparticle and magnetic hyperthermia therapy, and intraoperative interventions for improving the outcome of targeted therapy. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
尽管目前在癌症检测和治疗的新方法上取得了进展，但胰腺癌仍然是最致命的癌症类型之一。由于早期难以检测、肿瘤具有侵袭性的生物学特性以及对化疗、放疗和免疫疗法的耐药性，导致胰腺癌患者的预后较差，5 年生存率为 10%。随着癌症纳米技术的进步，新的成像和药物输送方法允许开发多功能纳米治疗剂，为使用精准肿瘤学改善胰腺癌治疗提供了机会。在这篇综述中，我们将介绍创新治疗策略的潜在应用，以解决不同疾病阶段胰腺癌治疗中的主要挑战。讨论了关于治疗性纳米粒子靶向递送和肿瘤基质屏障的几个重要问题。然后，我们专注于开发一种用于胰腺癌多模态治疗的磁性氧化铁纳米粒子平台，包括 MRI 监测靶向纳米粒子/药物输送、治疗反应和肿瘤重新分期、免疫激活纳米粒子激活肿瘤免疫反应和磁热疗，以及术中干预以提高靶向治疗的效果。本文属于以下类别： 生物学中的纳米技术方法 > 生物学中的纳米级系统 治疗方法和药物发现 > 用于肿瘤疾病的纳米医学 诊断工具 > 体内纳米诊断和成像。
