Gumusay Ozge, Huppert Laura A, Behr Spencer C, Rugo Hope S
Acibadem Altunizade Hospital, Breast Health Center, Istanbul, Turkey; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
Breast. 2022 Jun;63:149-156. doi: 10.1016/j.breast.2022.03.016. Epub 2022 Apr 2.
Patients with metastatic breast cancer are at high risk for developing vertebral compression fractures due to underlying bone metastases and bone density loss. Vertebral augmentation techniques including percutaneous vertebroplasty and percutaneous balloon kyphoplasty are techniques used to stabilize compression fractures and improve pain. However, rare complications from these interventions have been observed, including spinal cord compression, nerve root compression, venous cement embolism, and pulmonary cement embolism. These complications pose unique potential challenges for patients with cancer who may already have decreased lung function and potential for venous thromboembolism. In this review, we first describe the role of percutaneous vertebral augmentations in patients with metastatic cancer, with a particular focus on patients with breast cancer. Then, we describe complications of vertebral augmentation in two patients with metastatic breast cancer including long-term symptomatic and radiographic follow-up.
转移性乳腺癌患者因潜在的骨转移和骨密度降低而有发生椎体压缩性骨折的高风险。椎体增强技术，包括经皮椎体成形术和经皮球囊后凸成形术，是用于稳定压缩性骨折和缓解疼痛的技术。然而，已经观察到这些干预措施会出现罕见的并发症，包括脊髓压迫、神经根压迫、静脉骨水泥栓塞和肺骨水泥栓塞。这些并发症给可能已经存在肺功能下降和静脉血栓栓塞风险的癌症患者带来了独特的潜在挑战。在本综述中，我们首先描述经皮椎体增强术在转移性癌症患者中的作用，尤其关注乳腺癌患者。然后，我们描述两名转移性乳腺癌患者椎体增强术的并发症，包括长期的症状和影像学随访。
