Gonvers J J, Birchler R, Hofstetter J R, Pelloni S, Koelz H R, Blum A L
Schweiz Med Wochenschr. 1978 Jul 15;108(28):1081-3.
55 patients with endoscopically confirmed duodenal ulcers received either cimetidine (26 patients) or placebo (29 patients) in a double-blind trial. At four weeks, 85% of the patients treated with cimetidine and 62% of those receiving placebo had endoscopically healed ulcers. This difference is not statistically significant. However, patients on cimetidine showed a more rapid and statistically significant reduction in the size of their ulcers.
在一项双盲试验中，55例经内镜确诊为十二指肠溃疡的患者接受了西咪替丁治疗（26例）或安慰剂治疗（29例）。四周时，接受西咪替丁治疗的患者中有85%的溃疡在内镜检查下愈合，接受安慰剂治疗的患者中这一比例为62%。这一差异无统计学意义。然而，服用西咪替丁的患者溃疡大小的缩小更为迅速且具有统计学意义。
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