微生物聚羟基脂肪酸酯的结晶：综述

Crystallization of microbial polyhydroxyalkanoates: A review.

作者信息

Wang Qian, Xu Yunsheng, Xu Pengwu, Yang Weijun, Chen Mingqing, Dong Weifu, Ma Piming

机构信息

The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.

School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.

出版信息

Int J Biol Macromol. 2022 Jun 1;209(Pt A):330-343. doi: 10.1016/j.ijbiomac.2022.04.018. Epub 2022 Apr 6.

DOI:10.1016/j.ijbiomac.2022.04.018

PMID:35398060

Abstract

Polyhydroxyalkanoates (PHAs), produced by the microbial fermentation, is a promising green polymer and has attracted much attention due to its excellent biocompatibility, complete biodegradability, and non-cytotoxicity. The physical properties of PHAs are closely related to their chemical and crystalline structure. Therefore, deep understanding and regulating the structure and crystallization of PHAs are the key factors to improve the performance of PHAs. This review first provides a brief overview of the development history, chemical structure, and basic properties of PHAs. Then, the crystal structure, crystal morphology, kinetics theories and crystallization behavior of nucleation-induced PHAs are systematically summarized to provide a theoretical foundation for improving PHAs crystallization rate and physical properties. In the end, the outlook on the crystallization and application prospects of PHAs is also addressed.

摘要

聚羟基脂肪酸酯（PHA）由微生物发酵产生，是一种很有前景的绿色聚合物，因其优异的生物相容性、完全可生物降解性和无细胞毒性而备受关注。PHA的物理性质与其化学和晶体结构密切相关。因此，深入理解和调控PHA的结构与结晶是提高PHA性能的关键因素。本文综述首先简要概述了PHA的发展历史、化学结构和基本性质。然后，系统总结了成核诱导PHA的晶体结构、晶体形态、动力学理论和结晶行为，为提高PHA的结晶速率和物理性质提供理论基础。最后，还探讨了PHA的结晶及应用前景。