Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Phytochemistry. 2022 Jul;199:113171. doi: 10.1016/j.phytochem.2022.113171. Epub 2022 Apr 6.
Eight undescribed steroidal saponins named solasaponins A-H were isolated from the fruits of Solanum xanthocarpum, including an unusual 16,26-epoxy-furostanol saponin, two furostanol saponins, three isospirostanol saponins, two pseudo-spirostanol saponins. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HRESIMS) combined with physico-chemical analysis methods (acid hydrolysis, optical rotation, and IR). The cytotoxicities of all compounds in vitro against two human cancer cell lines (A-549 and HepG2) were evaluated by CCK-8 assay.
从茄科植物酸浆果实中分离得到 8 个未被描述的甾体皂苷，命名为索拉皂苷 A-H，包括一个不寻常的 16,26-环氧呋甾烷醇皂苷、两个呋甾烷醇皂苷、三个异螺甾烷醇皂苷、两个伪螺甾烷醇皂苷。所有化合物的结构均通过广泛的光谱数据分析（1D、2D NMR 和 HRESIMS）结合物理化学分析方法（酸水解、旋光度和 IR）进行阐明。通过 CCK-8 法评估了所有化合物在体外对两种人癌细胞系（A-549 和 HepG2）的细胞毒性。
