从. 的地下部分中分离得到的细胞毒甾体糖苷

Cytotoxic steroidal glycosides from the underground parts of .

机构信息

Department of Pharmacy, School of Medicine, Jinggangshan University, Ji'an 343009, China.

出版信息

J Asian Nat Prod Res. 2021 Sep;23(9):825-836. doi: 10.1080/10286020.2020.1787995. Epub 2020 Jul 11.

DOI:10.1080/10286020.2020.1787995

Abstract

A phytochemical study on the underground parts of yielded one new spirostanol saponin (), two new furostanol saponins ( and ), and one new pregnane glycoside (), along with three known compounds (). Their structures were elucidated on the basis of chemical and spectroscopic analysis. All isolated compounds were evaluated for their cytotoxic effects against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480). Compounds , , and showed cytotoxic activities with IC values of 3.21-17.06 μM.

摘要

对的地下部分进行的植物化学研究得到了一个新的螺旋甾烷皂苷（）、两个新的呋甾烷皂苷（和）和一个新的孕烷糖苷（），以及三个已知化合物（）。基于化学和光谱分析确定了它们的结构。所有分离得到的化合物均对五种人癌细胞系（HL-60、A-549、SMMC-7721、MCF-7 和 SW-480）的细胞毒性进行了评价。化合物、和表现出细胞毒性，IC 值为 3.21-17.06 μM。