Chen Jing-Ze, Fu Wu-Sheng, Xu Fei, Fang Qin-Mei, Zheng Kui-Cheng, Lin Zhong, Lin Yi-Ming, Zhang Sophia
The School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Department of Physical and Chemical Analysis, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, China.
The School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; Department of Physical and Chemical Analysis, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, China.
Toxicon. 2022 Jun;212:55-61. doi: 10.1016/j.toxicon.2022.04.001. Epub 2022 Apr 6.
Mushroom poisoning is a deeply concerning food safety problem that affects the public in China every year. Although there are statistics on the number of poisonings and incidents, there is a lack of data on the types of toxic mushrooms, clinical manifestations and toxins. A case of wild mushroom poisoning occurred in Xiamen. Descriptive epidemiological investigation, toxins detection, and morphological and phylogenetic identification were immediately performed. The patients exhibited typical neurotoxic symptoms after consuming wild mushrooms, including chills, vertigo, drowsiness, salivation and coma. The average incubation period was 30 min. Treatments that were adopted included fluid infusion, gastric lavage, catharsis, and liver protection treatment. All patients recovered within 10 days. The species was identified as Amanita pseudosychnopyramis, and its contents of muscarine, muscimol and ibotenic acid were 170.3 ± 5.9 mg/kg, 835.4 ± 43.1 mg/kg and 637.9 ± 54.8 mg/kg in dry weight, respectively, as detected by ultrahigh-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). To our knowledge, this is the first report of Amanita pseudosychnopyramis poisoning worldwide.
蘑菇中毒是一个令人深感担忧的食品安全问题，每年都在中国影响公众。尽管有中毒事件和事故的统计数据，但关于有毒蘑菇的种类、临床表现和毒素的数据却很缺乏。厦门发生了一起野生蘑菇中毒事件。随即开展了描述性流行病学调查、毒素检测以及形态学和系统发育鉴定。患者食用野生蘑菇后出现典型的神经毒性症状，包括寒战、眩晕、嗜睡、流涎和昏迷。平均潜伏期为30分钟。采取的治疗措施包括输液、洗胃、导泻和保肝治疗。所有患者均在10天内康复。该物种被鉴定为拟网纹鹅膏，通过超高效液相色谱串联质谱法（UPLC-MS/MS）检测，其干重中蝇蕈碱、毒蝇碱和鹅膏蕈氨酸的含量分别为170.3±5.9毫克/千克、835.4±43.1毫克/千克和637.9±54.8毫克/千克。据我们所知，这是全球首例拟网纹鹅膏中毒报告。
