Schüssler-Fiorenza Rose Sophia Miryam, Snyder Michael P, Slavich George M
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Prev Med. 2022 Jul;160:107044. doi: 10.1016/j.ypmed.2022.107044. Epub 2022 Apr 7.
Our objective was to examine how Adverse Childhood Experiences (ACEs) are associated with diabetes mellitus, diabetes-related conditions, and preventive care practices. We used data from the Behavioral Risk Factor Surveillance System (BRFSS) 2009-2012, a cross-sectional, population-based survey, to assess ACEs, diabetes, and health care access in 179,375 adults. In those with diabetes (n = 21,007), we assessed the association of ACEs with myocardial infarction, stroke, and five Healthy People 2020 (HP2020) diabetes-related preventive-care objectives (n = 13,152). Healthcare access indicators included lack of a regular health care provider, insurance, and difficulty affording health care. Regression analyses adjusted for age, sex, and race. The adjusted odds ratio (AOR) of diabetes increased in a stepwise fashion by ACE exposure, ranging from 1.2 (95% CI 1.1-1.3) for 1 ACE to 1.7 (95% CI 1.6-1.9) for ≥4 ACEs, versus having no ACEs. In persons with diabetes, those with ≥4 ACEs had an elevated adjusted odds of myocardial infarction (AOR = 1.6, 95% CI 1.2-2.0) and stroke (AOR = 1.8, 95% CI 1.3-2.4), versus having no ACEs. ACEs were also associated with a reduction in the adjusted percent of HP2020 diabetes objectives met: 72.9% (95% CI 71.3-74.5) for those with no ACEs versus only 66.5% (95% CI 63.8-69.3%) for those with ≥4 ACEs (p = 0.0002). Finally, ACEs predicted worse health care access in a stepwise fashion for all indicators. In conclusion, ACEs are associated with greater prevalence of diabetes and associated disease conditions, and with meeting fewer HP2020 prevention goals. Implementing ACE screening and trauma-informed health care practices are thus recommended.
我们的目标是研究童年不良经历(ACEs)与糖尿病、糖尿病相关病症及预防保健措施之间的关联。我们使用了2009 - 2012年行为危险因素监测系统(BRFSS)的数据,这是一项基于人群的横断面调查,以评估179,375名成年人的ACEs、糖尿病及医疗保健获取情况。在患有糖尿病的人群(n = 21,007)中,我们评估了ACEs与心肌梗死、中风以及五项《健康人民2020》(HP2020)糖尿病相关预防保健目标(n = 13,152)之间的关联。医疗保健获取指标包括没有固定的医疗保健提供者、没有保险以及难以负担医疗保健费用。回归分析对年龄、性别和种族进行了调整。与没有ACEs的人相比,糖尿病的调整后优势比(AOR)随着ACE暴露程度的增加而逐步上升,从1次ACE暴露的1.2(95%可信区间1.1 - 1.3)到≥4次ACE暴露的1.7(95%可信区间1.6 - 1.9)。在患有糖尿病的人群中,与没有ACEs的人相比,≥4次ACE暴露的人发生心肌梗死(AOR = 1.6,95%可信区间1.2 - 2.0)和中风(AOR = 1.8,95%可信区间1.3 - 2.4)的调整后优势增加。ACEs还与HP2020糖尿病目标达成的调整百分比降低相关:没有ACEs的人这一比例为72.9%(95%可信区间71.3 - 74.5),而≥4次ACE暴露的人仅为66.5%(95%可信区间63.8 - 69.3%)(p = 0.0002)。最后,对于所有指标,ACEs均以逐步方式预示着更差的医疗保健获取情况。总之,ACEs与糖尿病及相关疾病状况的更高患病率相关,且与达成更少的HP2020预防目标相关。因此,建议实施ACE筛查和创伤知情的医疗保健措施。