Famà Fausto, Pino Antonella, Cavallari Vittorio, Fadda Guido, Ieni Antonio, Dionigi Gianlorenzo
Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital G. Martino, University of Messina, Messina, Italy.
Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital G. Martino, University of Messina, Messina, Italy.
Int J Surg Case Rep. 2022 May;94:107031. doi: 10.1016/j.ijscr.2022.107031. Epub 2022 Apr 6.
Granular cell tumor (GCT) is a rare neurogenic neoplasm originating from Schwann cells that predominantly affects women and can involve skin and mucousae. In the respiratory system it most frequently involves bronchi and larynx, while it is rare in the trachea.
A 26-year old female smoker was hospitalized for a suspected hypoechoic nodule in the right thyroid lobe closely adherent to the trachea. At preoperative computed tomography tracheal lumen was totally clear. The patient underwent a total thyroidectomy with lymph node dissection and tracheal shaving. The postoperative course was complicated by an extensive subcutaneous bilatreral emphysema associated with respiratory distress appeared on the fifth day. Bronchoscopy revealed a right anterolateral subcentimeter lesion near the second tracheal ring. Histologically, the diagnosis was consistent with a tracheal GCT developing into the thyroid parenchyma. The patient was discharged on the twentieth postoperative day. At the follow-up bronchoscopy the lesion was completely healed and at the last 12 month follow-up the patient is doing well.
Tracheal tumors are uncommon neoplasms accounting for about 2% of the total respiratory tree tumors. In literature we found <50 papers concerning tracheal GCT and in almost all of the cases patients complained about respiratory symptoms.
We report here a rare case of benign GCT of the trachea with extraluminal development, in a young patient who did not complain about preoperative respiratory symptoms, presented on ultrasound as a thyroid nodule with suspected cytology.
颗粒细胞瘤（GCT）是一种罕见的神经源性肿瘤，起源于施万细胞，主要影响女性，可累及皮肤和黏膜。在呼吸系统中，它最常累及支气管和喉部，而在气管中则较为罕见。
一名26岁的吸烟女性因右甲状腺叶疑似低回声结节紧密附着于气管而住院。术前计算机断层扫描显示气管腔完全清晰。患者接受了全甲状腺切除术及淋巴结清扫和气管修整术。术后病程出现并发症，术后第五天出现广泛的双侧皮下气肿并伴有呼吸窘迫。支气管镜检查发现气管第二环附近右侧前外侧有一个小于1厘米的病变。组织学检查诊断为气管颗粒细胞瘤向甲状腺实质发展。患者术后第二十天出院。在随访支气管镜检查时，病变已完全愈合，在最后12个月的随访中，患者情况良好。
气管肿瘤是罕见的肿瘤，约占整个呼吸道肿瘤的2%。在文献中，我们发现关于气管颗粒细胞瘤的论文不到50篇，几乎所有病例患者都有呼吸道症状。
我们在此报告一例罕见的气管良性颗粒细胞瘤，肿瘤向管腔外生长，患者为年轻女性，术前无呼吸道症状，超声检查表现为甲状腺结节，细胞学检查可疑。
