利用Xe-CT功能图像进行容积调强弧形放疗计划可实现兼顾肺功能的放射治疗计划。
VMAT Planning With Xe-CT Functional Images Enables Radiotherapy Planning With Consideration of Lung Function.
作者信息
Utsumi Nobuko, Takahashi Takeo, Hatanaka Shogo, Hariu Masatsugu, Saito Mio, Kondo Shuichi, Soda Rikana, Nishimura Keiichiro, Yamano Takafumi, Watanabe Wataru, Shimbo Munefumi, Honda Norinari
机构信息
Department of Radiation Oncology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Department of Radiation Therapy, JCHO Tokyo Shinjuku Medical Center, Tokyo, Japan.
出版信息
Cancer Diagn Progn. 2021 Jul 3;1(3):193-200. doi: 10.21873/cdp.10026. eCollection 2021 Jul-Aug.
BACKGROUND/AIM: The most severe adverse event of radiotherapy in lung cancer is radiation pneumonitis (RP). Some indices commonly used to prevent RP are evaluated based on the anatomical lung volume. The irradiation dose may be more accurately assessed by using functional lung volume. We evaluated the usefulness of computed tomography (CT) incorporating functional ventilation images acquired by the inhalation of xenon (Xe) gas (Xe-CT functional images).
PATIENTS AND METHODS
Two plans were created for twelve patients: volumetric modulated arc therapy (VMAT) planning using conventional chest CT images (anatomical plans) and VMAT planning using Xe-CT functional images (functional plans), and the dosimetric parameters were compared.
RESULTS
Compared to the anatomical plans, the functional plans had significantly reduced V in the high-functional lungs (p=0.005), but significant differences were not seen in the moderate-functional and low-functional lungs.
CONCLUSION
The incorporation of Xe-CT functional images into VMAT plans enables radiotherapy planning with consideration of lung function.
背景/目的：肺癌放疗最严重的不良事件是放射性肺炎（RP）。一些常用于预防RP的指标是基于肺的解剖体积来评估的。通过使用功能性肺体积可能会更准确地评估照射剂量。我们评估了结合通过吸入氙气（Xe）获得的功能性通气图像的计算机断层扫描（CT）（Xe-CT功能图像）的实用性。
患者与方法
为12例患者制定了两种计划：使用传统胸部CT图像的容积调强弧形放疗（VMAT）计划（解剖计划）和使用Xe-CT功能图像的VMAT计划（功能计划），并比较剂量学参数。
结果
与解剖计划相比，功能计划在高功能肺中的V显著降低（p = 0.005），但在中功能肺和低功能肺中未观察到显著差异。
结论
将Xe-CT功能图像纳入VMAT计划能够在考虑肺功能的情况下进行放射治疗计划。
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