Huang Wei, Jiang Bo, Luo Jinli, Luo Meng, Ding Xiaoming, Yang Qian, Zhao Lin-Hua, Sun Qin-Guo, Tong Xiao-Lin
Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China.
Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Pharmacol. 2022 Mar 24;13:764305. doi: 10.3389/fphar.2022.764305. eCollection 2022.
To explore the effect of combining traditional Chinese medicine (TCM) and Western medicine in hemodialysis patients with coronavirus disease 2019 (COVID-19). This study was conducted from 27 January 2020 to 17 March 2020 in Wuhan Third Hospital Guanggu Branch, Wuhan, China. Fifty-three patients were included and divided into a control group (CG), which received Western medicine and a combined treatment group, which received TCM and Western medicine (TG). Clinical and laboratory data, TCM symptom scores, and chest computed tomography results were extracted and compared between the two groups. The TG included 21 (67.7%) men and 10 (32.3%) women with a mean age of 61.02 (standard deviation [SD] 15.07, range 26-89) years. The mean dialysis duration in the TG was 49 (SD 31) months. Of all patients in the TG, 27 (87.1%) had fatigue, 18 (58.1%) had dry cough, 16 (51.6%) had anorexia, 11 (35.5%) had dyspnea, and 11 (35.5%) had fever. The CG included 14 (63.6%) men and 8 (36.4%) women with a mean age of 61.45 (SD 13.78, range 36-84) years. The mean dialysis duration in the CG was 63 (SD 46) months. Of all patients in the CG, 21 (95.5%) had fatigue, 12 (54.5%) had dry cough, 17 (77.3%) had anorexia, 12 (54.5%) had dyspnea, and 7 (31.8%) had fever. After treatment, the TCM symptom scores of the two groups decreased; the anorexia scores were lower in the TG than in the CG ( < 0.05). After treatment, albumin increased and D-dimer, C-reactive protein, and lactate dehydrogenase levels decreased in the TG. The d-dimer levels were lower and the albumin level was higher in the TG than in the CG after treatment ( < 0.05). The cure rate was higher, and the mortality rate was lower in the TG than in the CG ( < 0.05). A combination of TCM and Western medicine in hemodialysis patients with COVID-19 could relieve symptoms and help recovery. Further evidence from larger randomized controlled trials is needed to confirm our results.
探讨中西医结合治疗对2019冠状病毒病（COVID-19）血液透析患者的影响。本研究于2020年1月27日至2020年3月17日在中国武汉第三医院光谷院区进行。纳入53例患者，分为对照组（CG），接受西医治疗；联合治疗组，接受中西医结合治疗（TG）。提取两组的临床和实验室数据、中医症状评分及胸部计算机断层扫描结果并进行比较。TG组包括21例（67.7%）男性和10例（32.3%）女性，平均年龄61.02岁（标准差[SD]15.07，范围26 - 89岁）。TG组的平均透析时长为49个月（SD 31）。TG组所有患者中，27例（87.1%）有乏力，18例（58.1%）有干咳，16例（51.6%）有食欲减退，11例（35.5%）有呼吸困难，11例（35.5%）有发热。CG组包括14例（63.6%）男性和8例（36.4%）女性，平均年龄61.45岁（SD 13.78，范围36 - 84岁）。CG组的平均透析时长为63个月（SD 46）。CG组所有患者中，21例（95.5%）有乏力，12例（54.5%）有干咳，17例（77.3%）有食欲减退，12例（54.5%）有呼吸困难，7例（31.8%）有发热。治疗后，两组的中医症状评分均降低；TG组的食欲减退评分低于CG组（<0.05）。治疗后，TG组的白蛋白升高，D - 二聚体、C反应蛋白及乳酸脱氢酶水平降低。治疗后，TG组的D - 二聚体水平低于CG组，白蛋白水平高于CG组（<0.05）。TG组的治愈率较高，死亡率低于CG组（<0.05）。中西医结合治疗COVID - 19血液透析患者可缓解症状并促进康复。需要更大规模随机对照试验的进一步证据来证实我们的结果。
