Xiong Wenping, Dai Qinglei, Wang Yingjun, Hou Zhiqiang, Lu Kunpeng, Sun Xiao, Duan Fujia, Wang Haibo, Zhang Daogong, Wang Mingming
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Psychol. 2022 Mar 24;13:818967. doi: 10.3389/fpsyg.2022.818967. eCollection 2022.
This study aimed to analyze the hearing improvement and prognosis factors of idiopathic sudden sensorineural hearing loss (ISSNHL) in different ages with initial total hearing loss.
We reviewed the medical records of 5,711 hospitalized patients with ISSNHL from 2016 to 2021 in our center. All of the patients had been treated with uniform combination drug therapy. After excluding the patients with initial partial hearing loss and those diagnosed with clear etiology, 188 patients were enrolled in this study and divided into six age groups (18-30, 31-40, 41-50, 51-60, 61-70, ≥ 71 years). In all groups, decreases in pure-tone average (PTA) 1 month posttreatment, effective rate, and clinical characteristics (vertigo, tinnitus, hospital stay, comorbidity, and inner ear magnetic resonance imaging) were analyzed.
Among the 188 enrolled patients, 86% had vertigo. Complete recovery was seen in 0.5% of patients, and marked recovery was seen in 43% of patients. The mean 1 month posttreatment PTAs were as follows: 18-30 years: 80 ± 7.5 dB; 31-40 years: 100 ± 9.0 dB; 41-50 years: 99 ± 8.3 dB; 51-60 years: 101 ± 8.6 dB; 61-70 years: 96 ± 9.6 dB; and ≥ 71 years: 88 ± 13.0 dB. Compared with the other groups, the 18-30- years group showed better recovery of hearing threshold in five frequencies (0.25, 0.5, 1, 2, and 4 kHz, respectively, at octave or semioctave frequencies under air conduction), and the recovery of hearing threshold at 0.25 and 0.5 Hz was better than the recovery at 1, 2, and 4 kHz. According to the results of the chi-square test statistical analysis, vertigo and comorbidities were associated with a poor prognosis of ISSNHL.
In summary, the treatment outcomes of patients with ISSNHL with initial total hearing loss were poor. There was a significant age-related difference with respect to marked recovery 1 month posttreatment, and the 18-30- years group showed better recovery than the other age groups.
本研究旨在分析不同年龄组初发时全聋的特发性突发性感音神经性听力损失（ISSNHL）患者的听力改善情况及预后因素。
我们回顾了2016年至2021年在本中心住院的5711例ISSNHL患者的病历。所有患者均接受了统一的联合药物治疗。排除初发时部分听力损失及病因明确的患者后，188例患者纳入本研究，并分为六个年龄组（18 - 30岁、31 - 40岁、41 - 50岁、51 - 60岁、61 - 70岁、≥71岁）。分析所有组治疗后1个月纯音平均听阈（PTA）下降情况、有效率及临床特征（眩晕、耳鸣、住院时间、合并症及内耳磁共振成像）。
188例纳入患者中，86%有眩晕症状。0.5%的患者完全恢复，43%的患者显著恢复。治疗后1个月的平均PTA如下：18 - 30岁：80±7.5dB；31 - 40岁：100±9.0dB；41 - 50岁：99±8.3dB；51 - 60岁：101±8.6dB；61 - 70岁：96±9.6dB；≥71岁：88±13.0dB。与其他组相比，18 - 30岁组在五个频率（气导下倍频程或半倍频程频率分别为0.25、0.5、1、2和4kHz）的听力阈值恢复较好，且0.25和0.5Hz的听力阈值恢复优于1、2和4kHz。根据卡方检验统计分析结果，眩晕和合并症与ISSNHL预后不良相关。
总之，初发时全聋的ISSNHL患者治疗效果较差。治疗后1个月显著恢复存在显著的年龄相关差异，18 - 30岁组比其他年龄组恢复更好。
