Higuchi K, Asai M, Suzuki M, Noguchi M, Ishihara M, Nakano M
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Nov;38(11):2045-9.
By measuring urinary trehalase which is localized in renal brush borders, we examined whether tubular dysfunction occurred or not during and after normal pregnancy. Urinary trehalase activity in 1st trimester, 2nd trimester, and 3rd trimester was increased significantly as compared with the controls (=non-pregnant women) (p less than 0.01). After delivery, urinary trehalase activity in puerperal 5th day was decreased to the level of the 1st trimester, and the activity of puerperal on the 30th day was in the range of the control value. Urinary beta 2-microglobulin (beta 2-MG) in the 1st trimester and 2nd trimester was not increased significantly as compared with the controls. Urinary beta 2-MG in the 3rd trimester, however, was significantly higher than that in the controls. After delivery, the value for beta 2-MG in puerperal on the 5th day was not decreased significantly as compared with the 3rd trimester, and in puerperal on the 30th day, urinary beta 2-MG was decreased to the control value. Urinary N-acetyl-beta-D-glucosaminidase (NAG) in the 3rd trimester was significantly higher than that in the controls (p less than 0.01) and in the 1st trimester (p less than 0.02). After delivery, a significant decrease was observed in urinary NAG between 5th puerperal day and the 3rd trimester. Moreover, urinary NAG on the 30th puerperal day was the level of the controls. On the basis of these results, it is inferred that tubular dysfunction is observed during normal pregnancy.
通过检测定位于肾刷状缘的尿海藻糖酶，我们研究了正常妊娠期间及产后是否发生肾小管功能障碍。与对照组（未怀孕女性）相比，妊娠早期、中期和晚期的尿海藻糖酶活性显著升高（p<0.01）。分娩后，产后第5天的尿海藻糖酶活性降至妊娠早期水平，产后第30天的活性在对照值范围内。与对照组相比，妊娠早期和中期的尿β2-微球蛋白（β2-MG）没有显著升高。然而，妊娠晚期的尿β2-MG显著高于对照组。分娩后，产后第5天的β2-MG值与妊娠晚期相比没有显著下降，产后第30天，尿β2-MG降至对照值。妊娠晚期的尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）显著高于对照组（p<0.01）和妊娠早期（p<0.02）。分娩后，观察到产后第5天与妊娠晚期之间尿NAG显著下降。此外，产后第30天的尿NAG处于对照水平。基于这些结果，推测正常妊娠期间存在肾小管功能障碍。
