Nakano M, Aoshima K, Katoh T, Teranishi H, Kasuya M, Katoh T
Institute for Medical Science of Aging, Aichi Medical University, Japan.
Environ Res. 1987 Dec;44(2):161-8. doi: 10.1016/s0013-9351(87)80224-4.
Urinary trehalase activity and leucine aminopeptidase activity were parabolically correlated with urinary beta 2-microglobulin, and these enzymes were observed to be biphasic in relation to urinary beta 2-microglobulin when the study populations included patients of Itai-itai disease and inhabitants of a cadmium-polluted area. Furthermore, urinary trehalase activity was parabolically correlated with urinary total protein and urinary glucose. From these results, it is inferred that by measuring both urinary trehalase and urinary beta 2-microglobulin, one can elucidate the degree of tubular damage.
尿海藻糖酶活性和亮氨酸氨肽酶活性与尿β2-微球蛋白呈抛物线相关，当研究人群包括痛痛病患者和镉污染地区居民时，观察到这些酶与尿β2-微球蛋白呈双相关系。此外，尿海藻糖酶活性与尿总蛋白和尿葡萄糖呈抛物线相关。从这些结果可以推断，通过测量尿海藻糖酶和尿β2-微球蛋白，可以阐明肾小管损伤的程度。
