Chin Edwin C, Leung Chit K, Yu Danny J, Yu Angus P, Bernal Joshua K, Lai Christopher W, Chan Derwin K C, Ngai Heidi H, Yung Patrick S H, Lee Chi H, Fong Daniel Y, Keating Shelley E, Coombes Jeff S, Siu Parco M
Division of Kinesiology, School of Public Health, The University of Hong Kong, Hong Kong, China.
Singapore Institute of Technology, Singapore.
J Exerc Sci Fit. 2022 Apr;20(2):161-171. doi: 10.1016/j.jesf.2022.03.003. Epub 2022 Mar 14.
This study aims to examine the effects of one-year, once-weekly high-intensity interval training (HIIT) on body adiposity and liver fat in adults with central obesity.
One-hundred and twenty adults aged 18-60 years with central obesity (body mass index ≥25, waist circumference ≥90 cm for men and ≥80 cm for women). This is an assessor-blinded randomized controlled trial. Participants will be randomly assigned to the HIIT group or the usual care control group. Each HIIT session will consist of 4 × 4-min bouts at 85%-95% maximal heart rate, interspersed with 3-min bouts at 50%-70% maximal heart rate. The HIIT group will complete one session per week for 12 months, whereas the usual care control group will receive health education. The primary outcomes of this study are total body adiposity and intrahepatic triglyceride content. The secondary outcomes include abdominal visceral adipose tissue, subcutaneous adipose tissue, body mass index, waist circumference, hip circumference, cardiorespiratory fitness, lean body mass, bone mineral density, blood pressure, fasting blood glucose, insulin, triglycerides, glycated hemoglobin, cholesterol profile, liver function enzymes, medications, adherence to exercise, adverse events, quality of life, and mental health. Outcome measure will be conducted at baseline, 12 months (post-intervention), and 24 months (one-year follow-up).
This study will explore the benefits of long-term once-weekly HIIT with a follow-up period to assess its effectiveness, adherence, and sustainability. We expect this intervention will enhance the practical suitability of HIIT in inactive adults with central obesity, and provide insights on low-frequency HIIT as a novel exercise option for the management of patients with central obesity and liver fat.
ClinicalTrials.gov (NCT03912272) registered on 11 April 2019.
本研究旨在探讨为期一年、每周一次的高强度间歇训练（HIIT）对中心性肥胖成年人身体肥胖和肝脏脂肪的影响。
120名年龄在18至60岁之间的中心性肥胖成年人（男性体重指数≥25，腰围≥90厘米；女性体重指数≥25，腰围≥80厘米）。这是一项评估者盲法随机对照试验。参与者将被随机分配到HIIT组或常规护理对照组。每次HIIT训练将包括4组4分钟的训练，强度为最大心率的85%-95%，中间穿插3分钟强度为最大心率50%-70%的训练。HIIT组将每周进行一次训练，持续12个月，而常规护理对照组将接受健康教育。本研究的主要结局是全身肥胖和肝内甘油三酯含量。次要结局包括腹部内脏脂肪组织、皮下脂肪组织、体重指数、腰围、臀围、心肺适能、瘦体重、骨密度、血压、空腹血糖、胰岛素、甘油三酯、糖化血红蛋白、血脂谱、肝功能酶、药物治疗、运动依从性、不良事件、生活质量和心理健康。结局测量将在基线、12个月（干预后）和24个月（一年随访）时进行。
本研究将探索长期每周一次HIIT的益处，并进行随访以评估其有效性、依从性和可持续性。我们预计这种干预将提高HIIT在不活跃的中心性肥胖成年人中的实际适用性，并为低频HIIT作为管理中心性肥胖和肝脏脂肪患者的新型运动选择提供见解。
ClinicalTrials.gov（NCT03912272）于2019年4月11日注册。
