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基因分型:深入观察欧洲。

Genotyping: A Closer Look Into Europe.

机构信息

SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain.

National Reference Laboratory for Toxoplasmosis, Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

出版信息

Front Cell Infect Microbiol. 2022 Mar 23;12:842595. doi: 10.3389/fcimb.2022.842595. eCollection 2022.

Abstract

is a major zoonotic agent which may cause harmful effects mainly in pregnant and immunocompromised hosts. Despite many efforts on its genetic characterization, an entirely clear picture of the population structure in Europe has not been achieved yet. The present study aimed to summarize the available genotyping information and to map the distribution of circulating strains. There is consensus on type II genotypes prevailing in Europe, but the absence of harmonization in the use of typing methods limits detailed knowledge. Standardized, high-end typing tools and integrative strategies are needed to fill the gaps and complete an accurate image of the genetic population in Europe.

摘要

是一种主要的人畜共患病原体,主要对孕妇和免疫功能低下的宿主造成有害影响。尽管在其基因特征方面做了很多努力,但目前尚未完全清楚地了解欧洲的种群结构。本研究旨在总结现有基因分型信息,并绘制流行菌株的分布情况。欧洲普遍存在 II 型基因型,但在分型方法的使用上缺乏协调一致,限制了详细的了解。需要标准化、高端的分型工具和综合策略来填补空白,完整准确地描绘欧洲的遗传种群图像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3173/8984497/ff088489c244/fcimb-12-842595-g001.jpg

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