Wen Yue, Jing Yukai, Yang Lu, Kang Danqing, Jiang Panpan, Li Na, Cheng Jiali, Li Jingwen, Li Xingbo, Peng Zican, Sun Xizi, Miller Heather, Sui Zhiwei, Gong Quan, Ren Boxu, Yin Wei, Liu Chaohong
Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China.
Department of Medical Imaging Technology, Clinical and Molecular Immunology Research Center, Medical school of Yangtze University, Jingzhou, Hubei, China.
Blood Sci. 2019 Oct 21;1(2):119-129. doi: 10.1097/BS9.0000000000000026. eCollection 2019 Oct.
B lymphocytes produce antibodies under the stimulation of specific antigens, thereby exerting an immune effect. B cells identify antigens by their surface B cell receptor (BCR), which upon stimulation, directs the cell to activate and differentiate into antibody generating plasma cells. Activation of B cells via their BCRs involves signaling pathways that are tightly controlled by various regulators. In this review, we will discuss three major BCR mediated signaling pathways (the PLC-γ2 pathway, PI3K pathway and MAPK pathway) and related regulators, which were roughly divided into positive, negative and mutual-balanced regulators, and the specific regulators of the specific signaling pathway based on regulatory effects.
B淋巴细胞在特定抗原的刺激下产生抗体，从而发挥免疫效应。B细胞通过其表面的B细胞受体（BCR）识别抗原，BCR受到刺激后，会引导细胞激活并分化为产生抗体的浆细胞。B细胞通过其BCR的激活涉及到由各种调节因子严格控制的信号通路。在这篇综述中，我们将讨论三种主要的BCR介导的信号通路（PLC-γ2通路、PI3K通路和MAPK通路）以及相关调节因子，这些调节因子大致分为正调节因子、负调节因子和相互平衡调节因子，以及基于调节作用的特定信号通路的特定调节因子。
