Yang Xiuxiu, Cong Tingting, He Hanqing, Wang Jianwei
School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Blood Sci. 2020 Dec 8;3(2):40-47. doi: 10.1097/BS9.0000000000000064. eCollection 2021 Apr.
GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown. Here, we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process. mice revealed no difference in the steady state of blood system while HSCs exhibited compromised reconstitution capacity due to increased apoptosis. Briefly, this study reveals that GSDME modulates HSC function by coordinating pyroptosis and apoptosis.
GSDME在其N端区域包含一个形成孔道的结构域以执行细胞焦亡。我们之前的研究报道过，[此处原文有缺失信息]的强制表达会损害造血干细胞（HSCs）的重建能力。然而，GSDME介导的细胞焦亡如何调节造血干细胞仍不清楚。在这里，我们表明造血干祖细胞能够在顺铂处理下发生细胞焦亡，并且GSDME是介导此过程的基因之一。[此处原文有缺失信息]小鼠在血液系统的稳态方面没有差异，而[此处原文有缺失信息]造血干细胞由于凋亡增加而表现出受损的重建能力。简而言之，这项研究揭示了GSDME通过协调细胞焦亡和凋亡来调节造血干细胞功能。
