Chen Zehui, Zheng Yaxin, Yang Yaling, Kang Junnan, You M James, Tian Chen
Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Blood Sci. 2021 Apr 28;3(2):29-34. doi: 10.1097/BS9.0000000000000071. eCollection 2021 Apr.
Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.
骨髓（BM）微环境调节并支持血细胞的生成，而血细胞是维持体内平衡所必需的。与正常造血类似，白血病发生起源于白血病干细胞（LSCs），后者可产生更多分化的恶性细胞。白血病细胞占据骨髓龛位并对其进行重构以支持白血病发生。异常的骨髓龛位是白血病干细胞的主要庇护所，在那里它们可以逃避化疗诱导的死亡并获得耐药性。在本综述中，我们重点关注骨髓龛位细胞对急性淋巴细胞白血病细胞的保护作用。
