Furuke Hirotaka, Matsubara Daiki, Kubota Takeshi, Kiuchi Jun, Kubo Hidemasa, Ohashi Takuma, Shimizu Hiroki, Arita Tomohiro, Yamamoto Yusuke, Konishi Hirotaka, Morimura Ryo, Shiozaki Atsushi, Kuriu Yoshiaki, Ikoma Hisashi, Fujiwara Hitoshi, Okamoto Kazuma, Otsuji Eigo
Division of Digestive Surgery, Department of Surgery,Kyoto Prefectural University of Medicine, Kyoto, Japan.
Cancer Diagn Progn. 2021 May 3;1(2):43-52. doi: 10.21873/cdp.10007. eCollection 2021 May-Jun.
The Geriatric Nutritional Risk Index (GNRI) is a nutritional measure for predicting the risk of morbidity and mortality in hospitalized patients. We evaluated the utility of the GNRI to predict the short-term and long-term outcomes after curative surgery for gastric cancer (GC).
Patients who underwent curative surgery for GC between 2008 and 2016 were reviewed (n=795). We classified patients into two groups according to the GNRI (high GNRI: low and no risk; low GNRI: major and moderate risk) and compared the utility of the GNRI.
A low GNRI was an independent prognostic factor for poorer overall survival (hazard ratio=2.34, p<0.001). The GNRI tended to be a better prognostic indicator in elderly patients with GC. Low GNRI was associated with postoperative complications (odds ratio=2.27, p=0.002), especially in patients aged ≥75 (odds ratio=2.26, p=0.042).
Low GNRI was associated with poor prognosis and occurrence of postoperative complications in patients with GC, especially in elderly patients.
老年营养风险指数（GNRI）是一种用于预测住院患者发病和死亡风险的营养指标。我们评估了GNRI对胃癌（GC）根治性手术后短期和长期预后的预测效用。
回顾性分析2008年至2016年间接受GC根治性手术的患者（n = 795）。我们根据GNRI将患者分为两组（高GNRI：低风险和无风险；低GNRI：高风险和中度风险），并比较GNRI的效用。
低GNRI是总体生存率较差的独立预后因素（风险比=2.34，p<0.001）。GNRI在老年GC患者中往往是更好的预后指标。低GNRI与术后并发症相关（比值比=2.27，p = 0.002），尤其是在年龄≥75岁的患者中（比值比=2.26，p = 0.042）。
低GNRI与GC患者的不良预后和术后并发症的发生相关，尤其是在老年患者中。
