评估尿路上皮癌中变异组织学的程度作为根治性膀胱切除术后临床结局的预测标志物。
Evaluation of the Extent of Variant Histology in Urothelial Carcinoma as a Predictive Marker of Clinical Outcomes After Radical Cystectomy.
作者信息
Minato Akinori, Noguchi Hirotsugu, Moriya Ryosuke, Higashijima Katsuyoshi, Yamasaki Gosuke, Kimuro Rieko, Hasegawa Yoshitaka, Tomisaki Ikko, Fujimoto Naohiro
机构信息
Department of Urology, School of Medicine,University of Occupational and Environmental Health, Kitakyushu, Japan.
Department of Pathology, Field of Oncology,Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
出版信息
Cancer Diagn Progn. 2021 Jul 3;1(4):345-351. doi: 10.21873/cdp.10046. eCollection 2021 Sep-Oct.
BACKGROUND/AIM: This study investigated the impact of the extent of variant histology (VH) on the prognosis of patients with bladder cancer (BC).
PATIENTS AND METHODS
We retrospectively evaluated consecutive patients with muscle-invasive BC who were treated with radical cystectomy (RC) at our institution between 2005 and 2018. Recurrence-free survival (RFS) and overall survival (OS) rates were evaluated using Kaplan-Meier analysis and Cox regression.
RESULTS
We identified 103 and 47 patients with pure urothelial carcinoma (UC) and a VH in UC, respectively. At the cutoff of 80%, univariate analysis identified significant differences in RFS (p=0.046) and OS (p=0.038) between patients with ≥80% VH (n=21) and those with <80% VH (n=26). Multivariate analysis revealed that the presence of ≥80% VH was significantly associated with RFS and OS.
CONCLUSION
The presence of ≥80% VH in UC could be an independent predictor of recurrence and mortality after RC.
背景/目的：本研究调查了变异组织学（VH）程度对膀胱癌（BC）患者预后的影响。
患者与方法
我们回顾性评估了2005年至2018年间在我院接受根治性膀胱切除术（RC）治疗的连续性肌肉浸润性BC患者。采用Kaplan-Meier分析和Cox回归评估无复发生存率（RFS）和总生存率（OS）。
结果
我们分别确定了103例纯尿路上皮癌（UC）患者和47例UC中存在VH的患者。在80%的临界值时，单因素分析发现VH≥80%的患者（n=21）与VH<80%的患者（n=26）在RFS（p=0.046）和OS（p=0.038）方面存在显著差异。多因素分析显示，VH≥80%与RFS和OS显著相关。
结论
UC中VH≥80%可能是RC术后复发和死亡的独立预测因素。
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