Fukui Kayo, Masumoto Norio, Yokoyama Erika, Kanou Akiko, Yokozaki Michiya, Sasada Shinsuke, Emi Akiko, Kadoya Takayuki, Arihiro Koji, Okada Morihito
Division of Laboratory Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine,Hiroshima University, Hiroshima, Japan.
Cancer Diagn Progn. 2021 Jul 3;1(4):309-316. doi: 10.21873/cdp.10041. eCollection 2021 Sep-Oct.
We investigated whether contrast-enhanced ultrasonography (CEUS) scores can predict lymphocyte-predominant breast cancer (LPBC).
We evaluated 75 patients who underwent US and CEUS. LPBC was defined as tissues with ≥50% stromal tumour-infiltrating lymphocytes (TILs) preoperatively. Characteristic US images predicting LPBC were evaluated using TIL-US scores via three ultrasonic tissue characteristics: Shape, internal echo level, and posterior echoes. TIL-CEUS was evaluated based on TIL-US plus CEUS.
TIL-US and TIL-CEUS cut-offs for predicting LPBC were 4 and 6 (area under the curve=0.93 and 0.96, respectively) points based on receiver operating characteristics curves. Sensitivity, specificity, and accuracy values (95% confidence intervaI) were 0.94 (0.77-0.99), 0.75 (0.70-0.77), and 0.80 (0.72-0.82); and 0.94 (0.78-0.99), 0.86 (0.81-0.87), and 0.88 (0.80-0.90) for TIL-US and TIL-CEUS, respectively. TIL-CEUS score was a significant single predictor for LPBC in multivariate logistic regression (p=0.001).
TIL-CEUS can be used for preoperative LPBC prediction and detection.
我们研究了超声造影（CEUS）评分是否能够预测淋巴细胞为主型乳腺癌（LPBC）。
我们评估了75例接受超声检查和CEUS检查的患者。LPBC术前定义为基质肿瘤浸润淋巴细胞（TILs）≥50%的组织。通过形状、内部回声水平和后方回声这三个超声组织特征，使用TIL-US评分来评估预测LPBC的特征性超声图像。TIL-CEUS基于TIL-US加CEUS进行评估。
基于受试者工作特征曲线，预测LPBC的TIL-US和TIL-CEUS截断值分别为4分和6分（曲线下面积分别为0.93和0.96）。TIL-US和TIL-CEUS的敏感性、特异性和准确性值（95%置信区间）分别为0.94（0.77 - 0.99）、0.75（0.70 - 0.77）、0.80（0.72 - 0.82）；以及0.94（0.78 - 0.99）、0.86（0.81 - 0.87）、0.88（0.80 - 0.90）。在多因素逻辑回归中，TIL-CEUS评分是LPBC的显著单一预测指标（p = 0.001）。
TIL-CEUS可用于LPBC的术前预测和检测。
