Melas Nikolaos
specialistläkare, sektionen för gastroenterologi och hepatologi, Centralsjukhuset Karlstad.
Lakartidningen. 2022 Apr 8;119:21118.
Eosinophilic gastrointestinal disease is a rare condition of unknown cause with rising incidence in adults and characterized by chronic inflammation in the gastrointestinal tract with accumulation of eosinophils in the gastrointestinal wall, without other apparent cause (e.g., infections, IBD). There are three types of eosinophilic gastrointestinal disease, classified according to the location of the eosinophilic infiltration: eosinophilic esophagitis, eosinophilic gastroenteritis, and eosinophilic colitis. A combination of clinical suspicion, histologic evidence of eosinophilic infiltration, and exclusion of other causes of tissue eosinophilia leads to the diagnosis. Elimination diet, corticosteroid therapy, and steroid-sparing agents are currently used to treat eosinophilic gastrointestinal disease.
嗜酸性粒细胞性胃肠病是一种病因不明的罕见疾病，在成人中的发病率呈上升趋势，其特征是胃肠道慢性炎症伴嗜酸性粒细胞在胃肠壁积聚，且无其他明显病因（如感染、炎症性肠病）。嗜酸性粒细胞性胃肠病有三种类型，根据嗜酸性粒细胞浸润的部位分类：嗜酸性粒细胞性食管炎、嗜酸性粒细胞性胃肠炎和嗜酸性粒细胞性结肠炎。临床怀疑、嗜酸性粒细胞浸润的组织学证据以及排除组织嗜酸性粒细胞增多的其他原因相结合可得出诊断。目前使用排除饮食、皮质类固醇治疗和类固醇替代药物来治疗嗜酸性粒细胞性胃肠病。
