一种来自（Guill. & Perr.）Taub.的新型倍半萜，原萜烯

A new sesquiterpene, prosoterpene, from (Guill. & Perr.) Taub.

作者信息

Ali Raza, Salawu Kayode Muritala, Aamer Muhammad, Jahan Humera, Tufail Priya, Irshad Rimsha, Khan Farooq-Ahmad, Sener Bilge, Choudhary M Iqbal, Wang Yan

机构信息

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

Department of Pharmacognosy and Drug Development, University of Ilorin, Ilorin, Nigeria.

出版信息

Nat Prod Res. 2023 Oct-Nov;37(19):3220-3227. doi: 10.1080/14786419.2022.2062755. Epub 2022 Apr 9.

DOI:10.1080/14786419.2022.2062755

PMID:35403496

Abstract

A new sesquiterpene (Prosoterpene, ) and eleven reported compounds (-) of several classes, such as flavonoids, alkaloids, phenolic acids, and long-chain alcohols, were isolated from the BuOH extract of (Guill. & Perr.) Taub. Compounds - were reported for the first time from this plant. Isomers and were separated for the first time. Extensive spectroscopic techniques and literature comparisons were used to characterise their structures. Furthermore, compounds , -, and - were performed for anti-glycation and cytotoxicity activities. Compound (quercetin-3---L-rhamnoside) exhibited moderate anti-glycation activity. All tested compounds were non-cytotoxic against MCF-7 (breast cancer), NCI-H460 (lung cancer), Hela (cervical cancer), and BJ (normal human fibroblast) cell lines.

摘要

从（Guill. & Perr.）Taub.的正丁醇提取物中分离出一种新的倍半萜（原萜烯）和11种已报道的几类化合物（-），如黄酮类、生物碱、酚酸和长链醇。化合物-首次从该植物中报道。异构体和首次被分离。采用广泛的光谱技术和文献比较来表征它们的结构。此外，对化合物、-和-进行了抗糖化和细胞毒性活性测试。化合物（槲皮素-3---L-鼠李糖苷）表现出中等的抗糖化活性。所有测试化合物对MCF-7（乳腺癌）、NCI-H460（肺癌）、Hela（宫颈癌）和BJ（正常人成纤维细胞）细胞系均无细胞毒性。