Fluoro and Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Academy of Scientific and Innovative Research, Ghaziabad 201002, India and.
Org Lett. 2022 Apr 22;24(15):2899-2904. doi: 10.1021/acs.orglett.2c00864. Epub 2022 Apr 11.
An efficient synthetic organic transformation was developed to access isoquinoline-substituted isobenzofurans by reaction of substituted 1,5-diynes with isoquinoline -oxides. Moderate to excellent yields of isoquinoline-derived isobenzofurans were achieved by formation of a new C-C and two C-O bonds in the presence of copper catalyst in one pot. whereas quinoline-substituted isobenzofurans were obtained when the reaction was conducted using quinoline -oxides and 1,5-diynes in the presence copper catalyst.
发展了一种有效的合成有机转化方法，通过取代的 1,5-二炔与异喹啉-氧化物的反应，来获得异喹啉取代的异苯并呋喃。在铜催化剂的存在下，一锅法中形成新的 C-C 和两个 C-O 键，以中等至优异的收率得到异喹啉衍生的异苯并呋喃。而当使用喹啉-氧化物和 1,5-二炔在铜催化剂存在下进行反应时，则得到喹啉取代的异苯并呋喃。
