Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Research Center of Quran, Hadith and Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nutr Health. 2023 Sep;29(3):591-597. doi: 10.1177/02601060221092203. Epub 2022 Apr 11.
nutritional factors might affect the number and function of immune cells for instance the production of cytokines and immunoglobulins. Ramadan fasting is intermittent abstinence from eating and drinking for almost four weeks. The present study aimed to investigate the influence of intermittent fasting on serum IgA, salivary IgA (sIgA), interleukin (IL)-17, and IL-22 levels. 40 healthy men aged 19-29 years were evaluated before and during the fourth week of Ramadan fasting for IgA levels by the nephelometric method as well as salivary IgA (sIgA), IL-17, and IL-22 amounts using enzyme-linked immunosorbent assay (ELISA). serum IgA levels reduced significantly at the end of Ramadan fasting (225.8 ± 87 vs. 196 ± 70 mg/dl) (p-value<0.001); however, sIgA amounts did not differ between before and the last week of Ramadan. Serum IL-17 reduced significantly (2.93 ± 1.51 vs. 2.17 ± 1.33 pg/ml) (p-value = 0.006) whereas IL-22 levels remained approximately unchanged. four weeks of intermittent fasting during Ramadan reduced the serum levels of IgA and IL-17 but did not affect the production of sIgA and IL-22. These findings indicate a limited impact of intermittent fasting on mucosal immunity.
营养因素可能会影响免疫细胞的数量和功能，例如细胞因子和免疫球蛋白的产生。斋月禁食是指将近四周的时间内，间歇性地禁食和饮水。本研究旨在探讨间歇性禁食对血清 IgA、唾液 IgA（sIgA）、白细胞介素（IL）-17 和 IL-22 水平的影响。评估了 40 名年龄在 19-29 岁的健康男性，在斋月禁食的第四周前后，通过散射比浊法检测 IgA 水平，以及通过酶联免疫吸附试验（ELISA）检测唾液 IgA（sIgA）、IL-17 和 IL-22 含量。在斋月禁食结束时，血清 IgA 水平显著降低（225.8±87 与 196±70 mg/dl）（p 值<0.001）；然而，sIgA 量在斋月前后没有差异。血清 IL-17 显著降低（2.93±1.51 与 2.17±1.33 pg/ml）（p 值=0.006），而 IL-22 水平保持不变。斋月期间四周的间歇性禁食降低了血清 IgA 和 IL-17 水平，但对 sIgA 和 IL-22 的产生没有影响。这些发现表明间歇性禁食对粘膜免疫的影响有限。
