Develioglu Omer Necati, Kucur Mine, Ipek Havva Duru, Celebi Saban, Can Gunay, Kulekci Mehmet
Department of Otorhinolaryngology, Head and Neck Surgery, Taksim Training and Research Hospital, Istanbul, Turkey.
J Int Med Res. 2013 Apr;41(2):463-72. doi: 10.1177/0300060513476424. Epub 2013 Feb 21.
To investigate the effects of Ramadan fasting on serum concentrations of immunoglobulin (Ig)G and IgM, and salivary IgA concentrations.
Blood and saliva samples were collected one week before and during the last week of Ramadan from healthy male volunteers. Albumin, total lymphocyte count, electrolytes, and IgG and IgM concentrations were determined in serum; salivary IgA concentrations were measured. Anthropometric measurements were also recorded.
Samples were collected from 35 subjects (mean age 35.86 years, range 20-59 years). Weight, body mass index, albumin levels and the nutritional risk index decreased significantly during Ramadan fasting compared with before fasting. In addition, Na(+) and Cl(-) electrolyte levels were significantly decreased during Ramadan. Serum IgG concentrations decreased significantly during Ramadan compared with before fasting, but were still within the normal range. Salivary IgA concentrations also decreased significantly, whereas serum IgM levels did not change. Lymphocyte numbers increased significantly, but there was no correlation between Ig levels and lymphocyte count.
Ramadan fasting did not result in severe immunological disturbances.
研究斋月禁食对血清免疫球蛋白（Ig）G和IgM浓度以及唾液IgA浓度的影响。
在斋月前一周和斋月最后一周期间，从健康男性志愿者身上采集血液和唾液样本。测定血清中的白蛋白、总淋巴细胞计数、电解质以及IgG和IgM浓度；测量唾液IgA浓度。还记录了人体测量数据。
从35名受试者（平均年龄35.86岁，范围20 - 59岁）采集了样本。与禁食前相比，斋月禁食期间体重、体重指数、白蛋白水平和营养风险指数显著下降。此外，斋月期间Na(+)和Cl(-)电解质水平显著降低。与禁食前相比，斋月期间血清IgG浓度显著下降，但仍在正常范围内。唾液IgA浓度也显著下降，而血清IgM水平没有变化。淋巴细胞数量显著增加，但Ig水平与淋巴细胞计数之间没有相关性。
斋月禁食并未导致严重的免疫紊乱。
