眼结节病患者光学相干断层扫描血管造影黄斑血管密度测量的定量评估。
Quantitative Evaluation of Macular Vessel Density Measurement by Optical Coherence Tomography Angiography in Patients with Inactive Ocular Sarcoidosis.
机构信息
Faculty of Medicine, Department of Ophthalmology, Başkent University, Ankara, Turkey.
Faculty of Medicine, Department of Biostatistics, Başkent University, Ankara, Turkey.
出版信息
Ocul Immunol Inflamm. 2023 May;31(4):689-695. doi: 10.1080/09273948.2022.2044057. Epub 2022 Apr 11.
PURPOSE
To evaluate the macular vessel density (VD) in inactive ocular sarcoidosis (OS) and investigate the relationship between VD and both disease duration and visual acuity (VA).
METHODS
This cross-sectional study was performed at a tertiary hospital. The macular VDs of patients with OS were obtained using optical coherence tomography angiography and compared with healthy subjects.
RESULTS
Deep whole image macular VD (WI-MVD), parafoveal, and perifoveal VDs were lower in OS group (p = .01, p = .01, p = .02, respectively). Negative correlation between disease duration and both superficial and deep WI-MVD, parafoveal, and perifoveal VDs was obtained (for all p < .05). There was a positive correlation between VA and superficial VD (p < .001, r = 0.848 for WI-MVD).
CONCLUSION
OS affects deep VD significantly. Changes in superficial VD affect VA more. Disease duration is an important factor affecting macular VD.
目的
评估活动性眼结节病（OS）的黄斑血管密度（VD），并研究 VD 与疾病持续时间和视力（VA）之间的关系。
方法
本横断面研究在一家三级医院进行。使用光相干断层扫描血管造影术获得 OS 患者的黄斑 VD，并与健康受试者进行比较。
结果
OS 组的深层全像黄斑 VD（WI-MVD）、旁中心和中心凹旁 VD 较低（p =.01，p =.01，p =.02，分别）。疾病持续时间与浅层和深层 WI-MVD、旁中心和中心凹旁 VD 呈负相关（均 p <.05）。VA 与浅层 VD 呈正相关（p <.001，WI-MVD 的 r = 0.848）。
结论
OS 显著影响深层 VD。浅层 VD 的变化对 VA 的影响更大。疾病持续时间是影响黄斑 VD 的一个重要因素。
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