Sangoram Rohini, Mahendradas Padmamalini, Bhakti Mishra Sai, Kawali Ankush, Sanjay Srinivasan, Shetty Rohit
Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India.
Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, India.
Ocul Immunol Inflamm. 2022 Jul;30(5):1260-1264. doi: 10.1080/09273948.2022.2055580. Epub 2022 Apr 11.
To describe a case of herpes simplex virus 1 (HSV 1) infection following coronavirus disease 2019 (COVID-19) vaccination in an Asian Indian female.
Retrospective case report.
A 40-year-old female presented with decreased vision, pain, and photophobia of 2 weeks duration. She reported receiving the second dose of COVISHIELD (ChAdOx1-S [recombinant]) 1 week prior to the onset of ocular symptoms. Left eye examination revealed granulomatous anterior uveitis. Aqueous sample from the left eye tested positive for HSV1 by polymerase chain reaction(PCR) method. She was managed with oral antiviral therapy, topical steroids, and cycloplegic agent and showed significant improvement of inflammation within 1 week and resolved within 3 weeks.
This report demonstrates a potential association of HSV 1 anterior uveitis with COVID-19 vaccination. A high index of suspicion of viral etiology is warranted when uveitis presents with reduced corneal sensations and pigmented keratic precipitates, following a recent history of COVID-19 vaccination.
描述一名亚洲印度女性在接种2019冠状病毒病（COVID-19）疫苗后发生单纯疱疹病毒1型（HSV 1）感染的病例。
回顾性病例报告。
一名40岁女性出现视力下降、疼痛和畏光症状，持续2周。她报告在眼部症状出现前1周接种了第二剂COVISHIELD（ChAdOx1-S[重组]）。左眼检查显示肉芽肿性前葡萄膜炎。通过聚合酶链反应（PCR）方法检测左眼房水样本HSV1呈阳性。她接受了口服抗病毒治疗、局部使用类固醇和睫状肌麻痹剂，炎症在1周内显著改善，并在3周内消退。
本报告证明了HSV 1前葡萄膜炎与COVID-19疫苗接种之间的潜在关联。近期有COVID-19疫苗接种史，当葡萄膜炎伴有角膜感觉减退和色素性角膜后沉着物时，应高度怀疑病毒病因。
