应用扫频源光学相干断层成像/光学相干断层成像血管造影技术分析 COVID-19 患儿的微血管。
Analysis of Microvasculature in Children Recovered from COVID-19 Using Swept-Source OCT/OCTA Technology.
机构信息
Department of Ophthalmology, Samsun Gazi Community Hospital, Samsun, Turkey.
Department of Pediatrics, Samsun Training and Research Hospital, Samsun, Turkey.
出版信息
Ocul Immunol Inflamm. 2023 May;31(4):721-727. doi: 10.1080/09273948.2022.2054431. Epub 2022 Apr 11.
PURPOSE
To analyze structural and vascular changes of the retina and choroid in pediatric patients with coronavirus disease 2019 (COVID-19) using optical coherence tomography (OCT)/OCT angiography (OCTA).
METHODS
This comparative cross-sectional study consists of the COVID-19 group including pediatric COVID-19 patients and the control group including healthy children. Vessel density (VD), central macular thickness,, and choroidal thickness (ChT) measurements were performed using swept-source OCT/OCTA 12 weeks after the recovery from COVID-19.
RESULTS
The mean VD measurements in the central fovea and nasal quadrants of all three retinal layers and choriocapillaris showed insignificantly lower values in the COVID-19 group when compared to the control group (0:002 < p < 0:05 for all). Similar to VD measurements, insignificant lower ChT measurements were obtained in the central fovea and nasal points in the COVID-19 group.
CONCLUSION
OCTA can be used as a non-invasive and valid biomarker in the assessment of early microvascular dysfunction associated with COVID-19.
目的
利用光学相干断层扫描（OCT）/OCT 血管造影术（OCTA）分析儿童 2019 冠状病毒病（COVID-19）患者的视网膜和脉络膜的结构和血管变化。
方法
本研究为回顾性病例对照研究，COVID-19 组包括儿科 COVID-19 患者，对照组包括健康儿童。在 COVID-19 康复 12 周后，使用扫频源 OCT/OCTA 进行血管密度（VD）、中心黄斑厚度（CMT）和脉络膜厚度（ChT）测量。
结果
与对照组相比，COVID-19 组所有三层视网膜和脉络膜毛细血管的中央凹和鼻象限的平均 VD 测量值显著较低（所有 p 值均为 0.002< p < 0.05）。与 VD 测量值相似，COVID-19 组中央凹和鼻点的 ChT 测量值也较低。
结论
OCTA 可作为评估 COVID-19 相关早期微血管功能障碍的一种非侵入性和有效的生物标志物。
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