• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长链非编码 RNA BMPR1B-AS1 通过海绵吸附 miR-7-2-3p 来调节 DCLK1/Akt/NF-κB 通路，促进子宫内膜癌细胞的增殖和转移。

Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway.

机构信息

Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan, China.

Academy of Medical Science, Zhengzhou University, Henan, Zhengzhou China.

出版信息

Cell Cycle. 2022 Aug;21(15):1599-1618. doi: 10.1080/15384101.2022.2060003. Epub 2022 Apr 11.

DOI:10.1080/15384101.2022.2060003
PMID:35404759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9291686/
Abstract

Endometrial carcinoma (EC) originates from the endometrium and is one of the most common tumors in female patients, and its incidence has continued to increase in recent decades. LncRNAs are involved in the pathogenesis and metastasis of a variety of malignant tumors, which indicates that lncRNAs can be used as tumor diagnostic markers and potential therapeutic targets. In this study, we analyzed the RNA transcripts of EC cells from The Cancer Genome Atlas (TCGA) and first reported a novel lncRNA, BMPR1B-AS1, that was more highly expressed in endometrial cancer tissues than in adjacent tissues, and BMPR1B-AS1 could promote endometrial cancer cell proliferation and metastasis. Bioinformatics prediction and experimental results both suggested that BMPR1B-AS1 could modulate the malignant behaviors of endometrial cancer cell lines by sponging miR-7-2-3p to modulate DCLK1, and a DCLK1 inhibitor blocked the activation of the PI3K/Akt/NF-κB signaling pathway. Collectively, this study suggests that the BMPR1B-AS1/miR-7-2-3p/DCLK1 axis contributes to the proliferation and metastasis of endometrial cancer cells via the PI3K/Akt/NF-κB pathway.

摘要

子宫内膜癌（EC）起源于子宫内膜，是女性患者中最常见的肿瘤之一，近年来其发病率持续上升。lncRNAs 参与多种恶性肿瘤的发病机制和转移，表明 lncRNAs 可以作为肿瘤诊断标志物和潜在的治疗靶点。在本研究中，我们分析了来自癌症基因组图谱（TCGA）的 EC 细胞的 RNA 转录物，首次报道了一种新型 lncRNA，BMPR1B-AS1，其在子宫内膜癌组织中的表达高于相邻组织，BMPR1B-AS1 可促进子宫内膜癌细胞的增殖和转移。生物信息学预测和实验结果均表明，BMPR1B-AS1 可以通过海绵 miR-7-2-3p 来调节 DCLK1，从而调节子宫内膜癌细胞系的恶性行为，DCLK1 抑制剂阻断了 PI3K/Akt/NF-κB 信号通路的激活。综上所述，本研究表明，BMPR1B-AS1/miR-7-2-3p/DCLK1 轴通过 PI3K/Akt/NF-κB 通路促进子宫内膜癌细胞的增殖和转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/4f71bcf9ea1f/KCCY_A_2060003_F0010_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/88d11b130a5d/KCCY_A_2060003_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/9cc8a610f8e6/KCCY_A_2060003_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/634115833d2b/KCCY_A_2060003_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/eb2483f60bb5/KCCY_A_2060003_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/457efbe2ab5c/KCCY_A_2060003_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/3e591eddcaa6/KCCY_A_2060003_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/610deac488c3/KCCY_A_2060003_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/c156f9d48a0d/KCCY_A_2060003_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/8b4ecc86163d/KCCY_A_2060003_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/4f71bcf9ea1f/KCCY_A_2060003_F0010_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/88d11b130a5d/KCCY_A_2060003_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/9cc8a610f8e6/KCCY_A_2060003_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/634115833d2b/KCCY_A_2060003_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/eb2483f60bb5/KCCY_A_2060003_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/457efbe2ab5c/KCCY_A_2060003_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/3e591eddcaa6/KCCY_A_2060003_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/610deac488c3/KCCY_A_2060003_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/c156f9d48a0d/KCCY_A_2060003_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/8b4ecc86163d/KCCY_A_2060003_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a9c/9291686/4f71bcf9ea1f/KCCY_A_2060003_F0010_C.jpg

相似文献

1
Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway.长链非编码 RNA BMPR1B-AS1 通过海绵吸附 miR-7-2-3p 来调节 DCLK1/Akt/NF-κB 通路，促进子宫内膜癌细胞的增殖和转移。
Cell Cycle. 2022 Aug;21(15):1599-1618. doi: 10.1080/15384101.2022.2060003. Epub 2022 Apr 11.
2
Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer.长链非编码 RNA ZEB1-AS1 下调通过 miR-342-3p/CUL4B 轴调控 PI3K/AKT/mTOR 信号通路抑制前列腺癌细胞增殖、迁移和侵袭。
Cancer Biother Radiopharm. 2020 Nov;35(9):661-672. doi: 10.1089/cbr.2019.3123. Epub 2020 Apr 9.
3
lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p.lncRNA OIP5-AS1 通过海绵吸附 miR-200c-3p 调控 PTEN/AKT 抑制子宫内膜癌细胞增殖和侵袭。
J Immunol Res. 2021 Jul 28;2021:4861749. doi: 10.1155/2021/4861749. eCollection 2021.
4
LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer.长链非编码 RNA-HNF1A-AS1 通过海绵吸附 miR-30b-3p 作为竞争性内源性 RNA 激活胃癌中的 PI3K/AKT 信号通路。
Br J Cancer. 2020 Jun;122(12):1825-1836. doi: 10.1038/s41416-020-0836-4. Epub 2020 Apr 27.
5
Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR-153-3p/ZNRF2 axis.长链非编码 RNA TTN-AS1 通过调节 miR-153-3p/ZNRF2 轴促进甲状腺乳头状癌的发生。
J Gene Med. 2019 May;21(5):e3083. doi: 10.1002/jgm.3083. Epub 2019 Mar 25.
6
Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3β pathway.长链非编码 RNA OGFRP1 的上调通过调节 miR-124-3p/SIRT1 轴和激活 PI3K/AKT/GSK-3β 通路促进子宫内膜癌。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2083-2090. doi: 10.1080/21691401.2019.1617727.
7
Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b.敲低长链非编码 RNA CCAT2 通过海绵吸附 miR-216b 抑制子宫内膜癌细胞的生长和转移。
Cancer Biomark. 2017 Dec 12;21(1):123-133. doi: 10.3233/CBM-170388.
8
Constructed the ceRNA network and predicted a FEZF1-AS1/miR-92b-3p/ZIC5 axis in colon cancer.构建 ceRNA 网络，预测结肠癌中 FEZF1-AS1/miR-92b-3p/ZIC5 轴。
Mol Cell Biochem. 2023 May;478(5):1083-1097. doi: 10.1007/s11010-022-04578-y. Epub 2022 Oct 11.
9
STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p/STAT3 axis and PI3K/AKT signalling pathway.STAT3 诱导的长链非编码 RNA ABHD11-AS1 的上调通过调节 miR-1301-3p/STAT3 轴和 PI3K/AKT 信号通路促进甲状腺乳头状癌的肿瘤进展。
Cell Prolif. 2019 Mar;52(2):e12569. doi: 10.1111/cpr.12569. Epub 2019 Jan 18.
10
LncRNA NR2F1-AS1 is involved in the progression of endometrial cancer by sponging miR-363 to target SOX4.长链非编码RNA NR2F1-AS1通过吸附miR-363靶向SOX4参与子宫内膜癌的进展。
Pharmazie. 2019 May 1;74(5):295-300. doi: 10.1691/ph.2019.8905.

引用本文的文献

1
The Role of Non-Coding RNAs in the Regulation of Oncogenic Pathways in Breast and Gynaecological Cancers.非编码RNA在乳腺癌和妇科癌症致癌途径调控中的作用
Noncoding RNA. 2025 Aug 6;11(4):61. doi: 10.3390/ncrna11040061.
2
Building a Hand-Curated ceRNET for Endometrial Cancer, Striving for Clinical as Well as Medicolegal Soundness: A Systematic Review.构建子宫内膜癌人工筛选的ceRNET，追求临床及法医学合理性：一项系统评价
Noncoding RNA. 2025 Apr 30;11(3):34. doi: 10.3390/ncrna11030034.
3
The role of ncRNAs and exosomes in the development and progression of endometrial cancer.

本文引用的文献

1
Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment.簇绒细胞和癌症干细胞标志物DCLK1：增强肿瘤微环境中抗肿瘤免疫的新靶点。
Cancers (Basel). 2020 Dec 17;12(12):3801. doi: 10.3390/cancers12123801.
2
Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark.癌症生物学特征中的天然反义转录本：隐藏在黑暗中的强大调控因子。
J Exp Clin Cancer Res. 2020 Sep 14;39(1):187. doi: 10.1186/s13046-020-01700-0.
3
Discovery of a selective inhibitor of doublecortin like kinase 1.
非编码RNA和外泌体在子宫内膜癌发生发展中的作用。
Front Oncol. 2024 Aug 12;14:1418005. doi: 10.3389/fonc.2024.1418005. eCollection 2024.
4
The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course-A Review.长链非编码RNA在子宫内膜癌病程中的促进和抑制作用——综述
Cancers (Basel). 2024 Jun 3;16(11):2125. doi: 10.3390/cancers16112125.
5
Advances in MiRNAs Involved in Endometrial Carcinoma.参与子宫内膜癌的微小RNA的研究进展
Comb Chem High Throughput Screen. 2025;28(1):3-11. doi: 10.2174/0113862073299444240308145725.
6
MicroRNAs, long non-coding RNAs, and circular RNAs and gynecological cancers: focus on metastasis.微小RNA、长链非编码RNA和环状RNA与妇科癌症：聚焦转移
Front Oncol. 2023 Oct 3;13:1215194. doi: 10.3389/fonc.2023.1215194. eCollection 2023.
7
Differential Expression of miRNAs in Amyotrophic Lateral Sclerosis Patients.肌萎缩侧索硬化症患者中 miRNAs 的差异表达。
Mol Neurobiol. 2023 Dec;60(12):7104-7117. doi: 10.1007/s12035-023-03520-7. Epub 2023 Aug 2.
8
Role of transforming growth factor-β in peripheral nerve regeneration.转化生长因子-β在外周神经再生中的作用。
Neural Regen Res. 2024 Feb;19(2):380-386. doi: 10.4103/1673-5374.377588.
9
Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review).非编码 RNA 与 Wnt/β-连环蛋白信号通路在子宫内膜癌中的作用（综述）。
Mol Med Rep. 2023 Aug;28(2). doi: 10.3892/mmr.2023.13037. Epub 2023 Jun 23.
10
The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer.长链非编码RNA、微小RNA及其相关信号通路在宫颈癌中的作用机制与诊断潜力
Front Cell Dev Biol. 2023 May 4;11:1170059. doi: 10.3389/fcell.2023.1170059. eCollection 2023.
双皮质素样激酶 1 的选择性抑制剂的发现。
Nat Chem Biol. 2020 Jun;16(6):635-643. doi: 10.1038/s41589-020-0506-0. Epub 2020 Apr 6.
4
Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells PI3K/Akt/NF-κB Signaling Pathway.圣草酚通过PI3K/Akt/NF-κB信号通路抑制胶质瘤细胞增殖、转移并诱导其凋亡。
Front Pharmacol. 2020 Feb 25;11:114. doi: 10.3389/fphar.2020.00114. eCollection 2020.
5
LncRNA LOXL1-AS1 promotes endometrial cancer progression by sponging miR-28-5p to upregulate RAP1B expression.长链非编码 RNA LOXL1-AS1 通过海绵吸附 miR-28-5p 来上调 RAP1B 表达，促进子宫内膜癌进展。
Biomed Pharmacother. 2020 May;125:109839. doi: 10.1016/j.biopha.2020.109839. Epub 2020 Jan 29.
6
Cancer statistics, 2020.癌症统计数据，2020 年。
CA Cancer J Clin. 2020 Jan;70(1):7-30. doi: 10.3322/caac.21590. Epub 2020 Jan 8.
7
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer.抑制 DCLK1 通过 Hippo 通路下调人胰腺癌中的 PD-L1 表达。
Life Sci. 2020 Jan 15;241:117150. doi: 10.1016/j.lfs.2019.117150. Epub 2019 Dec 11.
8
Long non-coding RNA ZEB1-AS1 promotes colon adenocarcinoma malignant progression via miR-455-3p/PAK2 axis.长链非编码 RNA ZEB1-AS1 通过 miR-455-3p/PAK2 轴促进结肠腺癌恶性进展。
Cell Prolif. 2020 Jan;53(1):e12723. doi: 10.1111/cpr.12723. Epub 2019 Dec 12.
9
LncRNA NEAT1 promotes endometrial cancer cell proliferation, migration and invasion by regulating the miR-144-3p/EZH2 axis.长链非编码 RNA NEAT1 通过调控 miR-144-3p/EZH2 轴促进子宫内膜癌细胞的增殖、迁移和侵袭。
Radiol Oncol. 2019 Nov 20;53(4):434-442. doi: 10.2478/raon-2019-0051.
10
Regulation of gene expression by cis-acting long non-coding RNAs.顺式作用长非编码 RNA 对基因表达的调控。
Nat Rev Genet. 2020 Feb;21(2):102-117. doi: 10.1038/s41576-019-0184-5. Epub 2019 Nov 15.