灵芝中含苯并吡喃或苯并呋喃母核的倍半萜。
Meroterpenoids containing benzopyran or benzofuran motif from Ganoderma cochlear.
机构信息
Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China; Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou, 521041, People's Republic of China.
出版信息
Phytochemistry. 2022 Jul;199:113184. doi: 10.1016/j.phytochem.2022.113184. Epub 2022 Apr 9.
Five undescribed benzopyran containing meroterpenoids, ganodercins Q－U, two undescribed benzofuran containing meroterpenoids, ganodercins V and W, and two known meroterpenoids were isolated from Ganoderma cochlear. Their structures were elucidated by using HRESIMS, NMR spectroscopy and computational methods. The results of biochemical studies using a palmitic acid (PA) induced insulin resistance (IR) model show that (-)-ganodercin Q, (+)-ganodercins R and W activate phospho-AKT (p-AKT) at 20 μM and improve glucose uptake in a concentration dependent manner. The results of renoprotection studies show that (+)-ganodercin S, cochlearol F, (+)- and (-)-ganodercins V reduce the expression of collagen I.
从灵芝中分离得到五个含苯并吡喃的混合倍半萜类化合物，灵芝醇 Q-U，两个含苯并呋喃的混合倍半萜类化合物，灵芝醇 V 和 W，以及两个已知的混合倍半萜类化合物。通过使用 HRESIMS、NMR 光谱和计算方法阐明了它们的结构。生化研究结果表明，在棕榈酸（PA）诱导的胰岛素抵抗（IR）模型中，（-）-灵芝醇 Q、（+）-灵芝醇 R 和 W 在 20 μM 时激活磷酸化 AKT（p-AKT），并呈浓度依赖性方式增加葡萄糖摄取。肾保护研究结果表明，（+）-灵芝醇 S、cochlearol F、（+）-和（-）-灵芝醇 V 降低胶原 I 的表达。
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