State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, PR China.
Phytochemistry. 2019 Jun;162:199-206. doi: 10.1016/j.phytochem.2019.03.019. Epub 2019 Apr 1.
Twelve previously undescribed phenolic meroterpenoids, cochlearols N-Y, along with two known analogs, ganocochlearins B and C, were isolated from the fruiting bodies of Ganoderma cochlear. Most of these substances were isolated as racemic mixtures. The structures of cochlearols N-Y were assigned based upon spectroscopic data and theoretical calculations. The renoprotective activities of these compounds were evaluated using normal and diseased rat renal interstitial fibroblast cells (NRK-49F). The results show that ganocochlearins S, U, X and Y display potent inhibitory activities against fibronectin overproduction in TGF-β1-induced NRK-49F cells.
从耳状革盖菌的子实体中分离得到了 12 种以前未描述的酚类倍半萜化合物 Cochlearols N-Y，以及两种已知的类似物 Ganocochlearins B 和 C。这些物质大多数都是外消旋混合物。基于光谱数据和理论计算，确定了 Cochlearols N-Y 的结构。采用正常和病变大鼠肾间充质成纤维细胞（NRK-49F）评估了这些化合物的肾保护活性。结果表明，Ganocochlearins S、U、X 和 Y 对 TGF-β1 诱导的 NRK-49F 细胞中纤连蛋白过度产生具有很强的抑制作用。
