从木耳 Ganoderma cochlear 中提取的具有肾保护作用的酚类杂萜。
Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, PR China.
出版信息
Phytochemistry. 2019 Jun;162:199-206. doi: 10.1016/j.phytochem.2019.03.019. Epub 2019 Apr 1.
Twelve previously undescribed phenolic meroterpenoids, cochlearols N-Y, along with two known analogs, ganocochlearins B and C, were isolated from the fruiting bodies of Ganoderma cochlear. Most of these substances were isolated as racemic mixtures. The structures of cochlearols N-Y were assigned based upon spectroscopic data and theoretical calculations. The renoprotective activities of these compounds were evaluated using normal and diseased rat renal interstitial fibroblast cells (NRK-49F). The results show that ganocochlearins S, U, X and Y display potent inhibitory activities against fibronectin overproduction in TGF-β1-induced NRK-49F cells.
从耳状革盖菌的子实体中分离得到了 12 种以前未描述的酚类倍半萜化合物 Cochlearols N-Y，以及两种已知的类似物 Ganocochlearins B 和 C。这些物质大多数都是外消旋混合物。基于光谱数据和理论计算，确定了 Cochlearols N-Y 的结构。采用正常和病变大鼠肾间充质成纤维细胞（NRK-49F）评估了这些化合物的肾保护活性。结果表明，Ganocochlearins S、U、X 和 Y 对 TGF-β1 诱导的 NRK-49F 细胞中纤连蛋白过度产生具有很强的抑制作用。
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