(±)-Gancochlearols J-N，来自珊瑚菌的具有肾保护作用的混合倍半萜。
(±)-Gancochlearols J - N, renoprotective meroterpenoids from Ganoderma cochlear.
机构信息
School of Medicine, Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China; School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China.
School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China.
出版信息
Bioorg Chem. 2021 Jul;112:104950. doi: 10.1016/j.bioorg.2021.104950. Epub 2021 Apr 26.
Five pairs of meroterpenoid enantiomers, (±)-gancochlearols J - N (1-5), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were elucidated on the basis of 1D and 2D NMR and HRESIMS data. The absolute configurations of gancochlearols J - M (1-4) were assigned by electronic circular dichroism (ECD) calculations. Biological evaluation showed that (-)-1 and (-)-2 could inhibit renal fibrosis in TGF-β1-induced rat kidney proximal tubular cells (NRK-52e).
五对倍半萜类对映异构体，（±）-gancochlearols J-N（1-5），从耳状灵芝的子实体中分离得到。基于 1D 和 2D NMR 和 HRESIMS 数据，确定了它们的结构。通过电子圆二色性（ECD）计算，确定了 gancochlearols J-M（1-4）的绝对构型。生物评价表明，（-）-1 和（-）-2 可以抑制 TGF-β1 诱导的大鼠肾近端肾小管细胞（NRK-52e）中的肾纤维化。
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