Wang Xin-Long, Zhou Feng-Jiao, Dou Man, Yan Yong-Ming, Wang Shu-Mei, Di Lei, Cheng Yong-Xian
Henan University of Chinese Medicine, Zhengzhou 450008, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Bioorg Med Chem Lett. 2016 Nov 15;26(22):5507-5512. doi: 10.1016/j.bmcl.2016.10.011. Epub 2016 Oct 7.
Ganoderma mushrooms are of great nutritious and medicinal values. This study was designed to characterize compounds from the fruiting bodies of Ganoderma cochlear and investigate their protective effects against kidney disorders. Six novel meroterpenoids cochlearoids F-K (1-6) were isolated by utilizing phytochemical approaches. Their structures were identified on the basis of extensive spectroscopic data and calculation methods. Biological evaluation shows that compounds 1-4 and 6 exhibit potent inhibitory activity on fibronectin overproduction in TGF-β1-induced HKC-8 cells.
灵芝具有很高的营养和药用价值。本研究旨在表征耳状灵芝子实体中的化合物，并研究它们对肾脏疾病的保护作用。通过植物化学方法分离得到了6种新型杂萜类化合物耳状灵芝素F-K（1-6）。基于广泛的光谱数据和计算方法确定了它们的结构。生物学评价表明，化合物1-4和6对TGF-β1诱导的HKC-8细胞中纤连蛋白过量产生具有显著的抑制活性。
