Lamesch A J, Dociu N
Microsurgery. 1986;7(4):203-7. doi: 10.1002/micr.1920070415.
The purpose of this study was to perfect the microsurgical technique of ureteroureterostomy in rats as a contribution to reconstructive surgery of the urinary tract in congenital malformations in newborns and infants. Microsurgical ureteroureterostomy was performed in 100 rats with Nylon and Vicryl 10-0 and 11-0 swaged on a BV-6 and BV-8 needle. Postoperative investigation of renal function and permeability of the anastomoses was realized by macroscopic examination and by IM urography. The healing of the anastomoses was studied at different intervals after operation by histologic and scanning electron microscopic evaluation. Results include 1) per primam healing without stenosis in 98% of the cases; 2) urine proof anastomosis achieved to avoid scarification; 3) extramucous sutures preferable to prevent leakage and also crystallization that rapidly occurs in the rat and 4) tubing or nephrostomy is unnecessary.
本研究的目的是完善大鼠输尿管输尿管吻合术的显微外科技术，为新生儿和婴儿先天性畸形的泌尿道重建手术提供帮助。使用尼龙线和10-0及11-0薇乔线，在BV-6和BV-8针上进行缝合，对100只大鼠实施显微外科输尿管输尿管吻合术。通过大体检查和静脉肾盂造影对肾功能及吻合口通透性进行术后评估。术后在不同时间间隔通过组织学和扫描电子显微镜评估研究吻合口的愈合情况。结果包括：1）98%的病例实现一期愈合且无狭窄；2）实现防尿吻合以避免瘢痕形成；3）黏膜外缝合更可取，可防止渗漏以及大鼠体内迅速发生的结晶；4）无需置管或肾造瘘。
