Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, United States.
Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, United States.
Curr Opin Neurobiol. 2022 Jun;74:102539. doi: 10.1016/j.conb.2022.102539. Epub 2022 Apr 8.
Schizophrenia is a severe and heritable neuropsychiatric disorder, which arises due to a combination of common genetic variation, rare loss of function variation, and copy number variation. Functional genomic evidence has been used to identify candidate genes affected by this variation, which revealed biological pathways that may be disrupted in schizophrenia. Understanding the contributions of these pathways are critical next steps in understanding schizophrenia pathogenesis. A number of genes involved in endocytosis are implicated in schizophrenia. In this review, we explore the history of endosomal trafficking in schizophrenia and highlight new endosomal candidate genes. We explore the function of these candidate genes and hypothesize how their dysfunction may contribute to schizophrenia.
精神分裂症是一种严重的遗传性神经精神疾病，是由常见的遗传变异、罕见的功能丧失变异和拷贝数变异共同作用引起的。功能基因组证据已被用于鉴定受这种变异影响的候选基因，这些基因揭示了可能在精神分裂症中被破坏的生物途径。了解这些途径的贡献是理解精神分裂症发病机制的关键下一步。许多参与内吞作用的基因与精神分裂症有关。在这篇综述中，我们探讨了精神分裂症中内体运输的历史，并强调了新的内体候选基因。我们探讨了这些候选基因的功能，并假设它们的功能障碍如何导致精神分裂症。
