Department of Obstetrics and Gynecology, Sakarya Training and Research Hospital, School of Medicine, Sakarya University, Sakarya, Turkey.
Department of Biochemistry, Muş State Hospital, Muş, Turkey.
Rev Bras Ginecol Obstet. 2022 May;44(5):458-466. doi: 10.1055/s-0042-1743101. Epub 2022 Apr 11.
Hyperemesis gravidarum (HG) is a pregnancy complication that can progress with persistent nausea and vomiting. The aim of the present study is to evaluate the relationship between hematological parameters and HG.
A total of 532 pregnant women with HG who were admitted to the Department of Obstetrics and Gynecology between March 2019 and February 2021, and 534 healthy pregnant women with characteristics similar to those of the case group were included in the study. The hematological parameters of both groups were compared. In addition, the hematological parametersof patients with HG according to the severity of ketonuria were compared.
The mean age of the HG group ( = 532) was 26.3 ± 4.1 years, and that of the control group ( = 534) was 25.9 ± 4.8 years. Among patients with HG, 46% ( = 249) had ketone (+), 33% ( = 174), ketone (++), and 21% ( = 109), ketone (++ + ). The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were higher in the HG group than in the control group: 3.8 (2.8-5.8)/3.2 (2.6-4.0); < 0.001; and 135.2 ± 30.4/108.9 ± 62.2; < 0.001 respectively. The neutrophil count, NLR, and PLR were higher in the group with ketone (++ + ) than in the groups with ketone (+) or ketone (++): 7.6 ± 1.9/5.5 ± 2.4; < 0.001; 3.8(2.8-4.6)/2.9(2.3-3.6); < 0.001; and 149.9 ± 48.0/135.9 ± 65.7; < 0.001 respectively. The mean corpuscular hemoglobin (MCH) level, the NLR, and the PLR were identified as independent predictors of the presence of HG and the level of ketone positivity in HG patients.
The NLR and PLR were high in patients with HG, suggesting the its inflammatory activity. They may be important markers associated with the presence and severity of HG.
妊娠剧吐（HG）是一种妊娠并发症，可表现为持续性恶心和呕吐。本研究旨在评估血液学参数与 HG 的关系。
选择 2019 年 3 月至 2021 年 2 月期间因 HG 入住妇产科的 532 例孕妇和 534 例具有相似特征的健康孕妇为研究对象。比较两组的血液学参数。此外，还比较了 HG 患者根据酮尿症严重程度的血液学参数。
HG 组（n=532）的平均年龄为 26.3±4.1 岁，对照组（n=534）的平均年龄为 25.9±4.8 岁。在 HG 患者中，46%（n=249）酮尿症（+），33%（n=174）酮尿症（++），21%（n=109）酮尿症（+++）。HG 组的中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）高于对照组：3.8（2.8-5.8）/3.2（2.6-4.0）； < 0.001；135.2 ± 30.4/108.9 ± 62.2； < 0.001。酮尿症（+++）组的中性粒细胞计数、NLR 和 PLR 高于酮尿症（+）或酮尿症（++）组：7.6 ± 1.9/5.5 ± 2.4； < 0.001；3.8（2.8-4.6）/2.9（2.3-3.6）； < 0.001；149.9 ± 48.0/135.9 ± 65.7； < 0.001。平均红细胞血红蛋白（MCH）水平、NLR 和 PLR 被鉴定为 HG 存在和 HG 患者酮尿症阳性程度的独立预测因子。
HG 患者的 NLR 和 PLR 较高，提示其炎症活性。它们可能是与 HG 的存在和严重程度相关的重要标志物。
